RAI1 Antibody (D-11): sc-365065

RAI1 Antibody (D-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects RAI1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). RAI1 (D-11) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. RAI1, also known as retinoic acid induced 1, is a 1,906 amino acid transcriptional regulator predominantly expressed in neuronal tissues, where RAI1 plays a crucial role in embryonic and postnatal development. RAI1 influences gene expression patterns essential for proper brain development and function. Notably, heterozygous deletions of RAI1 are linked to Smith-Magenis syndrome (SMS), a condition characterized by cognitive impairment, behavioral issues, and various physical anomalies. Individuals with SMS often exhibit self-injurious behaviors, sleep disturbances, and developmental delays, with RAI1 haploinsufficiency being specifically associated with obesity and craniofacial abnormalities. Additionally, mutations in RAI1 have been implicated in other neurological disorders, including schizophrenia and spinocerebellar ataxia type 2, highlighting RAI1′s significance in maintaining neurological health.

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RAI1 Antibody (D-11) References:

1. CAG repeat length in RAI1 is associated with age at onset variability in spinocerebellar ataxia type 2 (SCA2).  |  Hayes, S., et al. 2000. Hum Mol Genet. 9: 1753-8. PMID: 10915763
2. Mutations in RAI1 associated with Smith-Magenis syndrome.  |  Slager, RE., et al. 2003. Nat Genet. 33: 466-8. PMID: 12652298
3. Molecular cloning and characterization of human RAI1, a gene associated with schizophrenia.  |  Toulouse, A., et al. 2003. Genomics. 82: 162-71. PMID: 12837267
4. Mutations of RAI1, a PHD-containing protein, in nondeletion patients with Smith-Magenis syndrome.  |  Bi, W., et al. 2004. Hum Genet. 115: 515-24. PMID: 15565467
5. Diagnostic FISH probes for del(17)(p11.2p11.2) associated with Smith-Magenis syndrome should contain the RAI1 gene.  |  Vlangos, CN., et al. 2005. Am J Med Genet A. 132A: 278-82. PMID: 15690371
6. Inactivation of Rai1 in mice recapitulates phenotypes observed in chromosome engineered mouse models for Smith-Magenis syndrome.  |  Bi, W., et al. 2005. Hum Mol Genet. 14: 983-95. PMID: 15746153
7. RAI1 variations in Smith-Magenis syndrome patients without 17p11.2 deletions.  |  Girirajan, S., et al. 2005. J Med Genet. 42: 820-8. PMID: 15788730
8. [Results of additional studies on the performance-diagnostic screening test].  |  Rebohle, E., et al. 1977. Z Gesamte Hyg. 23: 896-9. PMID: 607642

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-RAI1 Antibody (D-11) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-RAI1 Antibody (D-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

RAI1 Antibody (D-11) Specifications

Alternate Product Name: RAI1

Product Clone Name: D-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 6-275

Epitope Target: RAI1

Epitope Species: human

Product Reactivity/Detection: RAI1 isoforms 1, 2, 3 and 4

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for RAI1 Antibody (D-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, B: Biotin, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin