Radical Fringe Antibody (18-K2): sc-100754

Radical Fringe Antibody (18-K2) is a mouse monoclonal IgG1 kappa light chain antibody that detects Radical Fringe protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Radical Fringe antibody (18-K2) is available as non-conjugated format. Radical Fringe protein, also known as Beta-1,3-N-acetylglucosaminyltransferase Radical Fringe, is a 331 amino acid single-pass type II membrane protein primarily localized to the membrane of the Golgi apparatus. Such localization enables Radical Fringe to play a significant role in glycosylation processes, particularly in transferring beta-D-GlcNAc residue from UDP-D-GlcNAc to fucosylated protein acceptors, essential for proper cell signaling and development. Radical Fringe protein serves as a key player in the Notch signaling pathway, influencing boundary determination during segmentation and contributing to limb bud development. Radical Fringe (18-K2) antibody recognizes a protein that interacts with other fringe family members, such as Lunatic Fringe and Manic Fringe, which are involved in developmental processes, including somite segmentation and tumorigenesis in certain cellular contexts. Diverse expression patterns of Radical Fringe across various tissues underscore its importance in both embryonic development and adult tissue function, making Radical Fringe protein a valuable target for research in developmental biology and related fields.

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Radical Fringe Antibody (18-K2) References:

1. Expression of Radical fringe in limb-bud ectoderm regulates apical ectodermal ridge formation.  |  Laufer, E., et al. 1997. Nature. 386: 366-73. PMID: 9121552
2. A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway.  |  Johnston, SH., et al. 1997. Development. 124: 2245-54. PMID: 9187150
3. Fringe boundaries coincide with Notch-dependent patterning centres in mammals and alter Notch-dependent development in Drosophila.  |  Cohen, B., et al. 1997. Nat Genet. 16: 283-8. PMID: 9207795
4. EWS/FLI1-induced manic fringe renders NIH 3T3 cells tumorigenic.  |  May, WA., et al. 1997. Nat Genet. 17: 495-7. PMID: 9398859
5. lunatic fringe is an essential mediator of somite segmentation and patterning.  |  Evrard, YA., et al. 1998. Nature. 394: 377-81. PMID: 9690473
6. The lunatic fringe gene is a target of the molecular clock linked to somite segmentation in avian embryos.  |  McGrew, MJ., et al. 1998. Curr Biol. 8: 979-82. PMID: 9742402
7. Differential expression pattern of the three Fringe genes is associated with epidermal differentiation.  |  Thélu, J., et al. 1998. J Invest Dermatol. 111: 903-6. PMID: 9804358

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Radical Fringe Antibody (18-K2) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Radical Fringe Antibody (18-K2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Radical Fringe Antibody (18-K2) Specifications

Alternate Product Name: Radical Fringe

Product Clone Name: 18-K2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 82-191

Epitope Target: Radical Fringe

Epitope Species: human

Product Reactivity/Detection: Radical Fringe

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Radical Fringe Antibody (18-K2): N/A