Radical Fringe Inhibitors
Radical Fringe Inhibitors encompass compounds that target the Notch signaling pathway, given RFNG's role as a glycosyltransferase modifying Notch receptors. The majority of these inhibitors focus on gamma-secretase, an enzyme responsible for the final cleavage step activating the Notch receptor. Gamma-secretase inhibitors, such as DAPT, Compound E, LY-411575, and RO4929097, prevent this crucial cleavage. By doing so, they effectively reduce the activation of the Notch pathway, indirectly modulating the glycosylation activity of RFNG, which is upstream of this cleavage event.
In addition to gamma-secretase inhibitors, other compounds act at different levels within the Notch pathway to exert an indirect effect on RFNG. For instance, compounds like FLI-06 disrupt intracellular transport associated with the Notch pathway.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $99.00 $335.00 $836.00 $2099.00 | 47 | |
Gamma-secretase inhibitor that prevents the final cleavage of Notch, thus indirectly affecting the pathway in which RFNG plays a role. | ||||||
Compound E | 209986-17-4 | sc-221433 sc-221433A sc-221433B | 250 µg 1 mg 5 mg | $122.00 $335.00 $948.00 | 12 | |
Another gamma-secretase inhibitor. By preventing Notch cleavage, it can influence the overall effectiveness of RFNG's glycosyltransferase activity. | ||||||
Dibenzazepine (Deshydroxy LY 411575) | 209984-56-5 | sc-207554 sc-207554A | 2 mg 5 mg | $100.00 $260.00 | 4 | |
Gamma-secretase inhibitor. Indirectly affects RFNG by targeting the downstream activation of the Notch receptor. | ||||||
RO-4929097 | 847925-91-1 | sc-364602 sc-364602A | 10 mg 50 mg | $430.00 $1389.00 | 1 | |
Notch signaling inhibitor that targets gamma-secretase, influencing the pathway and indirectly modulating the effectiveness of RFNG. | ||||||
LY411575 | 209984-57-6 | sc-364529 sc-364529A | 10 mg 50 mg | $194.00 $464.00 | 6 | |
Gamma-secretase inhibitor. Reduces Notch receptor activation, indirectly affecting processes that RFNG is involved in. | ||||||
L-685,458 | 292632-98-5 | sc-204042 sc-204042A | 1 mg 5 mg | $337.00 $1000.00 | 4 | |
Gamma-secretase inhibitor. By inhibiting this enzyme, the overall Notch pathway, including RFNG's role, can be influenced. | ||||||
FLI-06 | 313967-18-9 | sc-497529 | 5 mg | $82.00 | ||
Notch signal inhibitor that affects the intracellular transport. The disruption can indirectly modulate the function of RFNG. | ||||||
PF-3084014 | 1290543-63-3 | sc-507501 | 5 mg | $130.00 | ||
Gamma-secretase inhibitor, indirectly affects the glycosylation activity of RFNG by disrupting the overall Notch signaling. | ||||||
BMS-906024 | 1401066-79-2 | sc-507372 | 10 mg | $3600.00 | ||
Notch pathway inhibitor, specifically targeting gamma-secretase, can indirectly influence the function of RFNG. | ||||||
MK-0752 | 471905-41-6 | sc-364534 sc-364534A | 10 mg 50 mg | $592.00 $1550.00 | ||
Another gamma-secretase inhibitor. By acting on the Notch activation process, it indirectly modulates the role of RFNG in the pathway. | ||||||