Rad23B Antibody (E-10): sc-377409

Rad23B Antibody (E-10) is a mouse monoclonal IgM antibody that detects Rad23B in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Rad23B plays a critical role in the nucleotide excision repair (NER) pathway, which is essential for maintaining genomic stability by repairing UV-induced DNA damage. Rad23B is predominantly located in the nucleus, where Rad23B interacts with the 26S proteasome, facilitating the degradation of damaged proteins and thus preventing the accumulation of potentially harmful cellular debris. Rad23B (E-10) antibody helps detect a protein vital for the stability of the xeroderma pigmentosum C protein (XPC), as Rad23B absence significantly reduces XPC levels, highlighting Rad23B′s importance in the DNA damage response. Additionally, anti-Rad23B antibody (E-10) recognizes a conserved ubiquitin-like domain that is crucial for biological functions, underscoring Rad23B′s evolutionary significance from yeast to humans. Rad23B monoclonal antibody (E-10) serves as an invaluable tool for researchers studying DNA repair mechanisms and cellular response to genotoxic stress, providing insights into fundamental processes that protect cells from DNA damage.

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Rad23B Antibody (E-10) References:

1. Critical DNA damage recognition functions of XPC-hHR23B and XPA-RPA in nucleotide excision repair.  |  Thoma, BS. and Vasquez, KM. 2003. Mol Carcinog. 38: 1-13. PMID: 12949838
2. Human XPC-hHR23B interacts with XPA-RPA in the recognition of triplex-directed psoralen DNA interstrand crosslinks.  |  Thoma, BS., et al. 2005. Nucleic Acids Res. 33: 2993-3001. PMID: 15914671
3. hHR23B is required for genotoxic-specific activation of p53 and apoptosis.  |  Kaur, M., et al. 2007. Oncogene. 26: 1231-7. PMID: 16924240
4. PolyQ-expanded huntingtin and ataxin-3 sequester ubiquitin adaptors hHR23B and UBQLN2 into aggregates via conjugated ubiquitin.  |  Yang, H., et al. 2018. FASEB J. 32: 2923-2933. PMID: 29401586
5. Molecular basis for damage recognition and verification by XPC-RAD23B and TFIIH in nucleotide excision repair.  |  Mu, H., et al. 2018. DNA Repair (Amst). 71: 33-42. PMID: 30174301
6. Cytoplasmic RAD23B interacts with CORO1C to synergistically promote colorectal cancer progression and metastasis.  |  Li, J., et al. 2021. Cancer Lett. 516: 13-27. PMID: 34062216
7. Deubiquitinase PSMD7 promotes the proliferation, invasion, and cisplatin resistance of gastric cancer cells by stabilizing RAD23B.  |  Wang, J., et al. 2021. Int J Biol Sci. 17: 3331-3342. PMID: 34512150
8. Knockdown of circ-RAD23B inhibits non-small cell lung cancer progression via the miR-142-3p/MAP4K3 axis.  |  Zhuang, Q., et al. 2022. Thorac Cancer. 13: 750-760. PMID: 35106926
9. Identifying a novel KLF2/lncRNA SNHG12/miR-494-3p/RAD23B axis in Spare Nerve Injury-induced neuropathic pain.  |  Zhang, J., et al. 2022. Cell Death Discov. 8: 272. PMID: 35624111
10. HHR23B, a human Rad23 homolog, stimulates XPC protein in nucleotide excision repair in vitro.  |  Sugasawa, K., et al. 1996. Mol Cell Biol. 16: 4852-61. PMID: 8756644

The preferred Rad23B antibody is Rad23B Antibody (H-8): sc-137088.