Rad23B Antibody (C-4): sc-166507
- Rad23B Antibody (C-4) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- raised against amino acids 77-196 mapping within an internal region of Rad23B of human origin
- recommended for detection of Rad23B of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for Rad23B Antibody (C-4) for WB and IHC(P) applications. These reagents are now offered in bundles with Rad23B Antibody (C-4) (see ordering information below).
Rad23B Antibody (C-4) is a mouse monoclonal IgG2a antibody that detects Rad23B in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Rad23B plays a critical role in the nucleotide excision repair (NER) pathway, which is essential for maintaining genomic stability by repairing UV-induced DNA damage. Rad23B is predominantly located in the nucleus, where Rad23B interacts with the 26S proteasome, facilitating the degradation of damaged proteins and thus preventing the accumulation of potentially harmful cellular components. Rad23B (C-4) antibody helps detect this protein′s vital role in the stability of the xeroderma pigmentosum C protein (XPC), as Rad23B absence significantly reduces XPC levels, highlighting Rad23B importance in DNA repair mechanisms. Additionally, Rad23B contains a conserved ubiquitin-like domain that is crucial for biological functions, underscoring Rad23B evolutionary significance from yeast to humans. Anti-Rad23B antibody (C-4) serves as an invaluable tool for researchers studying DNA repair processes and the cellular response to genotoxic stress, providing insights into the molecular mechanisms underlying various diseases, including cancer.
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Rad23B Antibody (C-4) References:
- Photo-cross-linking of XPC-Rad23B to cisplatin-damaged DNA reveals contacts with both strands of the DNA duplex and spans the DNA adduct. | Neher, TM., et al. 2010. Biochemistry. 49: 669-78. PMID: 20028083
- Genetic polymorphisms in RAD23B and XPC modulate DNA repair capacity and breast cancer risk in Puerto Rican women. | Pérez-Mayoral, J., et al. 2013. Mol Carcinog. 52 Suppl 1: E127-38. PMID: 23776089
- Identification and functional validation of RAD23B as a potential protein in human breast cancer progression. | Linge, A., et al. 2014. J Proteome Res. 13: 3212-22. PMID: 24897598
- Interaction of Nucleotide Excision Repair Protein XPC-RAD23B with DNA Containing Benzo[a]pyrene-Derived Adduct and Apurinic/Apyrimidinic Site within a Cluster. | Starostenko, LV., et al. 2016. Biochemistry (Mosc). 81: 233-41. PMID: 27262192
- MicroRNA-196b enhances the radiosensitivity of SNU-638 gastric cancer cells by targeting RAD23B. | Shen, YN., et al. 2018. Biomed Pharmacother. 105: 362-369. PMID: 29864624
- Serum starvation raises turnover of phosphorylated p62/SQSTM1 (Serine 349), reveals expression of proteasome and N-glycanase1 interactive protein RAD23B and sensitizes human synovial fibroblasts to BAY 11-7085-induced cell death. | Relic, B., et al. 2018. Oncotarget. 9: 35830-35843. PMID: 30533198
- Upregulation of GRIM-19 augments the sensitivity of prostate cancer cells to docetaxel by targeting Rad23b. | Lin, H., et al. 2020. Clin Exp Pharmacol Physiol. 47: 76-84. PMID: 31531888
- Inhibition of Excision of Oxidatively Generated Hydantoin DNA Lesions by NEIL1 by the Competitive Binding of the Nucleotide Excision Repair Factor XPC-RAD23B. | Kolbanovskiy, M., et al. 2020. Biochemistry. 59: 1728-1736. PMID: 32302101
- Identifying a novel KLF2/lncRNA SNHG12/miR-494-3p/RAD23B axis in Spare Nerve Injury-induced neuropathic pain. | Zhang, J., et al. 2022. Cell Death Discov. 8: 272. PMID: 35624111
- FMNL3 Promotes Migration and Invasion of Breast Cancer Cells via Inhibiting Rad23B-Induced Ubiquitination of Twist1. | Zhao, B., et al. 2025. J Cell Physiol. 240: e31481. PMID: 39582466
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rad23B Antibody (C-4) | sc-166507 | 200 µg/ml | $322.00 | |||
Rad23B Antibody (C-4): m-IgG Fc BP-HRP Bundle | sc-540113 | 200 µg Ab; 10 µg BP | $361.00 | |||
Rad23B Antibody (C-4): m-IgG2a BP-HRP Bundle | sc-546853 | 200 µg Ab; 10 µg BP | $361.00 |