Rad18 Antibody (4H237): sc-71952
- Rad18 Antibody (4H237) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against amino acids 402-414 of Rad18 of human origin
- recommended for detection of Rad18 of human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Rad18 Antibody (4H237). This work is in progress.
Rad18 Antibody (4H237) is a mouse monoclonal IgG1 antibody that detects Rad18 in human samples through applications such as western blotting (WB) and immunoprecipitation (IP). Rad18 is a crucial RING-type zinc finger protein that plays a significant role in the post-replication repair of damaged DNA, thereby contributing to the maintenance of genomic stability. Rad18 is primarily localized in the nucleus, where anti-Rad18 antibody (4H237) can detect essential functions in the Rad54-dependent DNA repair pathway and the recruitment of ubiquitin-conjugating enzymes in the Rad6 pathway. The ability of Rad18 to facilitate gap-filling of a daughter strand during the replication of damaged DNA is vital for preventing mutations and ensuring the integrity of the genome. Furthermore, Rad18 undergoes post-translational modifications, including ubiquitination, which can regulate its activity and interactions with other proteins involved in DNA repair processes. Rad18 monoclonal antibody (4H237) enables researchers to gain valuable insights into the mechanisms of DNA repair and the implications of Rad18 in various cellular contexts, making this tool indispensable for studies focused on genomic stability and cancer research.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rad18 Antibody (4H237) | sc-71952 | 100 µg/ml | $316.00 |