Rad18 Antibody (79B1048): sc-52949

Rad18 Antibody (79B1048) is a mouse monoclonal IgG1 antibody that detects Rad18 protein of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-Rad18 antibody (79B1048) is available as a non-conjugated format. Rad18 (79B1048) antibody recognizes a protein that plays a crucial role in post-replication repair of damaged DNA, which is vital for maintaining genomic stability and preventing mutations that could lead to cancer. Specifically, Rad18 is involved in recruiting ubiquitin-conjugating enzymes within the Rad6 pathway, facilitating modification of proteins essential for DNA repair processes. Rad18 interacts with other key proteins, such as Rad54, to ensure effective repair of chromosomal DNA. This interaction helps fill gaps in daughter strands during replication of damaged DNA, thereby preserving genetic material integrity. Rad18 is predominantly localized in the nucleus, where DNA damage response functions occur.

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Rad18 Antibody (79B1048) References:

1. Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens.  |  Tateishi, S., et al. 2000. Proc Natl Acad Sci U S A. 97: 7927-32. PMID: 10884424
2. The human RAD18 gene product interacts with HHR6A and HHR6B.  |  Xin, H., et al. 2000. Nucleic Acids Res. 28: 2847-54. PMID: 10908344
3. RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.  |  Hoege, C., et al. 2002. Nature. 419: 135-41. PMID: 12226657
4. RAD18 and RAD54 cooperatively contribute to maintenance of genomic stability in vertebrate cells.  |  Yamashita, YM., et al. 2002. EMBO J. 21: 5558-66. PMID: 12374756
5. Enhanced genomic instability and defective postreplication repair in RAD18 knockout mouse embryonic stem cells.  |  Tateishi, S., et al. 2003. Mol Cell Biol. 23: 474-81. PMID: 12509447
6. Rad18 guides poleta to replication stalling sites through physical interaction and PCNA monoubiquitination.  |  Watanabe, K., et al. 2004. EMBO J. 23: 3886-96. PMID: 15359278
7. DNA damage-induced accumulation of Rad18 protein at stalled replication forks in mammalian cells involves upstream protein phosphorylation.  |  Nikiforov, A., et al. 2004. Biochem Biophys Res Commun. 323: 831-7. PMID: 15381075

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Rad18 Antibody (79B1048) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Rad18 Antibody (79B1048) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Rad18 Antibody (79B1048) Specifications

Alternate Product Name: Rad18

Product Clone Name: 79B1048

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids: 402-414

Epitope Target: Rad18

Epitope Species: human

Product Reactivity/Detection: Rad18

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Rad18 Antibody (79B1048): N/A