Rabex-5 Antibody (D-8): sc-166050

Rabex-5 Antibody (D-8) is a mouse monoclonal IgG2a antibody that detects Rabex-5 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Rabex-5, also known as RABGEF1, RAP1, or RABAPTIN-5-associated exchange factor for Rab 5, plays a crucial role as a guanine nucleotide exchange factor that facilitates the activation of Rab 5, a key regulator of endosomal trafficking. Rabex-5 is primarily located in the cytoplasm and associates with early endosomes, where Rabex-5 is essential for the proper functioning of intracellular transport processes. The structure of Rabex-5 includes an N-terminal zinc finger domain, a guanine nucleotide exchange factor domain, an early endosomal targeting domain, and a coiled-coil domain, each contributing to functional capabilities. Notably, the early endosomal targeting domain is vital for Rabex-5′s localization to early endosomes and interaction with Rab 5, ensuring efficient endosomal dynamics. The Rabex-5/RABAPTIN-5 complex, which forms through the binding of Rab5-GTP to RABAPTIN-5, enhances the targeting of early endosomes, underscoring the importance of Rabex-5 in cellular transport mechanisms. anti-Rabex-5 antibody (D-8) is an invaluable tool for researchers studying endosomal trafficking and the molecular pathways involved in cellular transport.

The preferred Rabex-5 antibody is Rabex-5 Antibody (A-7): sc-166611.