Rab 5C Antibody (D-6): sc-374041
- Rab 5C Antibody (D-6) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 186-216 at the C-terminus of Rab 5C of human origin
- recommended for detection of Rab 5C of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, bovine and porcine
- See Rab 5 (D-11): sc-46692 for Rab 5C antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Rab 5C Antibody (D-6) for WB applications. These reagents are now offered in bundles with Rab 5C Antibody (D-6) (see ordering information below).
Rab 5C Antibody (D-6) is a mouse monoclonal IgG1 antibody that detects Rab 5C in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Rab 5C plays a crucial role in the early stages of endocytosis and is essential for the transport of vesicles within cells, particularly in the movement of carrier vesicles from the plasma membrane to early endosomes. Rab 5C is primarily located on the cytoplasmic side of the membrane of early endosomes, where Rab 5C regulates the fusion of vesicles and the sorting of endocytosed materials. Proper functioning of Rab 5C is vital for maintaining cellular homeostasis and facilitating nutrient uptake, as well as for the recycling of membrane proteins. Dysregulation of Rab 5C has been implicated in various diseases, including neurodegenerative disorders, highlighting Rab 5C′s importance in cellular transport mechanisms. anti-Rab 5C antibody (D-6) is an invaluable tool for researchers studying vesicular trafficking and the molecular pathways involved in endocytosis, providing insights into the dynamic processes that govern cellular function.
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LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Rab 5C Antibody (D-6) References:
- Rab5 isoforms orchestrate a 'division of labor' in the endocytic network; Rab5C modulates Rac-mediated cell motility. | Chen, PI., et al. 2014. PLoS One. 9: e90384. PMID: 24587345
- Down-regulation of Ras-related protein Rab 5C-dependent endocytosis and glycolysis in cisplatin-resistant ovarian cancer cell lines. | Jin, L., et al. 2014. Mol Cell Proteomics. 13: 3138-51. PMID: 25096996
- Rab5C enhances resistance to ionizing radiation in rectal cancer. | Baptistella, AR., et al. 2019. J Mol Med (Berl). 97: 855-869. PMID: 30968159
- Rab5c-mediated endocytic trafficking regulates hematopoietic stem and progenitor cell development via Notch and AKT signaling. | Heng, J., et al. 2020. PLoS Biol. 18: e3000696. PMID: 32275659
- RAB5C, a new mRNA binding target of HuR, regulates breast cancer cell proliferation. | Wang, Z., et al. 2023. Cell Biol Int. 47: 374-382. PMID: 36480789
- Non-Rabl chromosome organization in endoreduplicated nuclei of barley embryo and endosperm tissues. | Nowicka, A., et al. 2023. J Exp Bot. 74: 2527-2541. PMID: 36705553
- Organelle-selective click labeling coupled with flow cytometry allows pooled CRISPR screening of genes involved in phosphatidylcholine metabolism. | Tsuchiya, M., et al. 2023. Cell Metab. 35: 1072-1083.e9. PMID: 36917984
- Nuclear genome organization in fungi: from gene folding to Rabl chromosomes. | Torres, DE., et al. 2023. FEMS Microbiol Rev. 47: PMID: 37197899
- Macrocephaly and developmental delay caused by missense variants in RAB5C. | Koop, K., et al. 2023. Hum Mol Genet. 32: 3063-3077. PMID: 37552066
- Rab5c promotes RSV and ADV replication by autophagy in respiratory epithelial cells. | Wang, X., et al. 2024. Virus Res. 341: 199324. PMID: 38242290
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rab 5C Antibody (D-6) | sc-374041 | 200 µg/ml | $322.00 | |||
Rab 5C Antibody (D-6): m-IgG Fc BP-HRP Bundle | sc-540416 | 200 µg Ab; 10 µg BP | $361.00 | |||
Rab 5C Antibody (D-6): m-IgG1 BP-HRP Bundle | sc-542106 | 200 µg Ab; 20 µg BP | $361.00 | |||
Rab 5C (D-6) Neutralizing Peptide | sc-374041 P | 100 µg/0.5 ml | $69.00 |