Rab 5C Inhibitors
Common Rab 5C Inhibitors include, but are not limited to EHT 1864 CAS 754240-09-0, Vacuolin-1 CAS 351986-85-1, Wortmannin CAS 19545-26-7, Dynamin Inhibitor I, Dynasore CAS 304448-55-3 and Bafilomycin A1 CAS 88899-55-2.
Rab 5C inhibitors belong to a specific chemical class of compounds designed to target and inhibit the activity of Ras-related protein Rab-5C (Rab 5C), a member of the Rab family of small GTPases. Rab 5C is involved in regulating intracellular membrane trafficking and plays a pivotal role in endocytic pathways, including early endosome formation and vesicle fusion processes. These processes are essential for the internalization, sorting, and transport of molecules within cells.
Rab 5C inhibitors work by specifically targeting the Rab 5C protein, interfering with its GTPase activity and its ability to regulate vesicle trafficking and endocytic pathways. By doing so, these inhibitors may modulate cellular processes that rely on proper endosomal trafficking, impacting various aspects of intracellular communication and compartmentalization. Research into Rab 5C inhibitors is ongoing to unravel their precise mechanisms of action and explore their implications in understanding cellular trafficking dynamics. The study of Rab 5C inhibitors contributes to a deeper understanding of the intricate mechanisms governing intracellular transport and cellular compartmentalization.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
EHT 1864 | 754240-09-0 | sc-361175 sc-361175A | 10 mg 50 mg | $209.00 $872.00 | 12 | |
EHT 1864 is a small molecule inhibitor known to target Rac family GTPases. As Rab5c can interact with Rac1, inhibiting Rac1 could potentially disrupt Rab5c-mediated cellular processes like endocytosis and membrane trafficking. | ||||||
Vacuolin-1 | 351986-85-1 | sc-216045 | 10 mg | $260.00 | 29 | |
Vacuolin is known to disrupt endosome fusion, which could indirectly affect Rab5c-regulated processes. By inhibiting endosome fusion, Vacuolin might influence the maturation of Rab5c-positive endosomes and their interactions with downstream effectors. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a PI3K inhibitor that can affect endocytic pathways. By targeting PI3K, Wortmannin could disrupt Rab5c-associated membrane trafficking processes that rely on PI3K-dependent lipid signaling and affect endosome maturation and vesicle trafficking. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine is an autophagy inhibitor that might indirectly impact Rab5c-associated processes. Autophagy and endocytic pathways often intersect, and inhibiting autophagy with Chloroquine could potentially affect Rab5c-mediated membrane trafficking and organelle dynamics. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $87.00 | 44 | |
Dynasore is known to inhibit dynamin, which is involved in vesicle fission processes. Rab5c-mediated endocytic pathways could be affected by Dynasore, as dynamin inhibition might impact the fission of Rab5c-positive early endosomes and their subsequent maturation. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
Bafilomycin A1 is a vacuolar ATPase inhibitor that might influence Rab5c-regulated endosome acidification and maturation. By inhibiting vacuolar ATPase activity, Bafilomycin A1 could potentially impact the progression of Rab5c-positive endosomes along the endocytic pathway. | ||||||
Pitstop 2 | 1419093-54-1 | sc-507418 | 10 mg | $360.00 | ||
Pitstop 2 is known to target clathrin-mediated endocytosis. As Rab5c-associated endocytic pathways often involve clathrin-coated vesicles, Pitstop 2 might indirectly impact Rab5c-mediated vesicle trafficking processes by affecting the formation of clathrin-coated structures. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $152.00 $515.00 | ||
Monensin is an ionophore known to affect vesicular trafficking. By altering intracellular ion gradients, Monensin could indirectly impact Rab5c-regulated endosome dynamics and vesicle trafficking processes, potentially influencing the maturation and sorting of Rab5c-positive endosomes. | ||||||
5-(N-Ethyl-N-isopropyl)-Amiloride | 1154-25-2 | sc-202458 | 5 mg | $102.00 | 20 | |
EIPA is known to inhibit Na+/H+ exchangers, affecting endosome acidification. As Rab5c-positive endosomes rely on proper acidification for maturation, EIPA could indirectly influence Rab5c-mediated endocytic pathways by altering endosome pH and subsequent downstream effects. | ||||||