Rab 3A Antibody (H-8): sc-365872
- Rab 3A Antibody (H-8) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 199-220 at the C-terminus of Rab 3A of human origin
- recommended for detection of Rab 3A of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for Rab 3A Antibody (H-8) for WB applications. These reagents are now offered in bundles with Rab 3A Antibody (H-8) (see ordering information below).
Rab 3A Antibody (H-8) is a mouse monoclonal IgG2a antibody that detects Rab 3A in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Rab 3A is a member of the Rab family of small GTPases, which play a crucial role in the regulation of vesicle trafficking within cells. Specifically, Rab 3A is predominantly located in neuronal tissues and is essential for the exocytosis of neurotransmitters from synaptic vesicles, making Rab 3A vital for proper synaptic function and communication between neurons. The precise localization of Rab 3A at the synapse underscores Rab 3A′s importance in neurotransmitter release, which is fundamental for processes such as learning and memory. Additionally, Rab 3A is known to interact with various effector proteins that facilitate the docking and fusion of synaptic vesicles with the presynaptic membrane, further highlighting Rab 3A′s critical role in synaptic transmission. With an ability to provide insights into the mechanisms of vesicle transport and neurotransmitter release, anti-Rab 3A antibody (H-8) serves as an invaluable tool for researchers studying neuronal function and related disorders.
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Rab 3A Antibody (H-8) References:
- Amino acid residues in the Ras-like GTPase Rab3A that specify sensitivity to factors that regulate the GTP/GDP cycling of Rab3A. | Burstein, ES., et al. 1992. J Biol Chem. 267: 22715-8. PMID: 1331063
- Myosin5a tail associates directly with Rab3A-containing compartments in neurons. | Wöllert, T., et al. 2011. J Biol Chem. 286: 14352-61. PMID: 21349835
- Rab3A mediates vesicle delivery at photoreceptor ribbon synapses. | Tian, M., et al. 2012. J Neurosci. 32: 6931-6. PMID: 22593061
- Rab3a promotes brain tumor initiation and progression. | Kim, JK., et al. 2014. Mol Biol Rep. 41: 5903-11. PMID: 24965146
- Rab3A, Rab27A, and Rab35 regulate different events during mouse oocyte meiotic maturation and activation. | Wang, HH., et al. 2016. Histochem Cell Biol. 145: 647-57. PMID: 26791531
- A Rab3a-dependent complex essential for lysosome positioning and plasma membrane repair. | Encarnação, M., et al. 2016. J Cell Biol. 213: 631-40. PMID: 27325790
- Localization of Rab3A-binding site on C2A domain of synaptotagmin I to reveal its regulatory mechanism. | Tang, X., et al. 2017. Int J Biol Macromol. 96: 736-742. PMID: 28057568
- The role of Rab3A in neurotransmitter release. | Geppert, M., et al. 1994. Nature. 369: 493-7. PMID: 7911226
- GDP/GTP exchange reaction-stimulating activity of Rabphilin-3A for Rab3A small GTP-binding protein. | Fujita, Y., et al. 1994. FEBS Lett. 353: 67-70. PMID: 7926025
- Role of the Rab3A-binding domain in targeting of rabphilin-3A to vesicle membranes of PC12 cells. | McKiernan, CJ., et al. 1996. Mol Cell Biol. 16: 4985-95. PMID: 8756657
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rab 3A Antibody (H-8) | sc-365872 | 200 µg/ml | $322.00 | |||
Rab 3A Antibody (H-8): m-IgG Fc BP-HRP Bundle | sc-540380 | 200 µg Ab; 10 µg BP | $361.00 | |||
Rab 3A Antibody (H-8): m-IgG2a BP-HRP Bundle | sc-546898 | 200 µg Ab; 10 µg BP | $361.00 | |||
Rab 3A (H-8) Neutralizing Peptide | sc-365872 P | 100 µg/0.5 ml | $69.00 |