Rab 3 GAP p130 Antibody (H-1): sc-393524

Rab 3 GAP p130 Antibody (H-1) is a mouse monoclonal IgG2b antibody that detects Rab 3 GAP p130 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Rab 3 GAP p130, also known as Rab3 GTPase-activating protein catalytic subunit, is a crucial 981 amino acid protein that plays a significant role in regulating neurotransmitter and hormone exocytosis. Rab 3 GAP p130 is essential for converting active RAB3-GTP to inactive RAB3-GDP, thereby facilitating normal eye and brain development. Notably, defects in Rab 3 GAP p130 are linked to Warburg micro syndrome 1 (WARBM1), a severe autosomal recessive disorder characterized by developmental abnormalities in the eye and central nervous system, as well as microgenitalia. Rab 3 GAP p130 is involved in critical neurodevelopmental processes, including cell proliferation, migration, and differentiation prior to synapse formation, as well as non-synaptic vesicular release of neurotransmitters. Rab 3 GAP p130 exists in two alternatively spliced isoforms and is conserved across various species, including chimpanzees, dogs, cows, mice, chickens, zebrafish, and fruit flies, with its gene located on human chromosome 2q21.3. Anti-Rab 3 GAP p130 antibody (H-1) versatility in various applications makes this reagent an invaluable tool for researchers studying neurodevelopmental processes and related disorders.

The preferred Rab 3 GAP p130 antibody is Rab 3 GAP p130 Antibody (G-3): sc-393540.