R2/p53R2 Antibody (F-9): sc-376973
- R2/p53R2 Antibody (F-9) is a mouse monoclonal IgG2b κ, cited in 7 publications, provided at 200 µg/ml
- raised against amino acids 90-389 mapping at the C-terminus of R2 of human origin
- Anti-R2/p53R2 Antibody (F-9) is recommended for detection of R2 and p53 R2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including canine
- Anti-R2/p53R2 Antibody (F-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG2b BP-HRP are the preferred secondary detection reagents for R2/p53R2 Antibody (F-9) for WB and IHC(P) applications. These reagents are now offered in bundles with R2/p53R2 Antibody (F-9) (see ordering information below).
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SEE ALSO...
R2/p53R2 Antibody (F-9) is a mouse monoclonal IgG2b kappa light chain antibody, designed to detect both R2 and p53R2 proteins, also known as RRM2 and RRM2B, across mouse, rat, human, and additional species including canine. R2/p53R2 monoclonal antibody (F-9) targets an epitope comprising amino acids 90-389 at the C-terminus of human R2/p53R2, ensuring precise and reliable binding for a variety of applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). The R2/p53R2 proteins are essential subunits of ribonucleotide reductase, an enzyme complex crucial for the synthesis and maintenance of deoxyribonucleoside triphosphates (dNTPs) required for DNA replication and repair. Structurally, R2/p53R2 interacts with the R1 subunit to form the active ribonucleotide reductase complex, regulating dNTP production during the S-phase of the cell cycle and in response to DNA damage. Additionally, p53R2 interacts with the tumor suppressor protein p53, facilitating the supply of dNTPs necessary for DNA repair processes following genotoxic stress. These interactions are vital for maintaining genomic stability and preventing mutations that could lead to cancer. anti-R2/p53R2 antibody (F-9) enables researchers to study these critical protein-protein interactions, enhancing the understanding of cell cycle regulation, DNA damage response, and the molecular mechanisms underlying tumor suppression. The broad species reactivity and high specificity of R2/p53R2 (F-9) antibody make it an indispensable tool for investigating the functional dynamics of ribonucleotide reductase in various biological contexts. Whether utilized in basic research or clinical studies, R2/p53R2 monoclonal antibody (F-9) delivers exceptional performance and reliability, supporting advancements in cancer research and the development of therapeutic strategies targeting DNA repair pathways.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
R2/p53R2 Antibody (F-9) | sc-376973 | 200 µg/ml | $316.00 | |||
R2/p53R2 Antibody (F-9): m-IgG Fc BP-HRP Bundle | sc-526068 | 200 µg Ab; 10 µg BP | $354.00 | |||
R2/p53R2 Antibody (F-9): m-IgG2b BP-HRP Bundle | sc-549672 | 200 µg Ab; 10 µg BP | $354.00 | |||
R2/p53R2 Antibody (F-9) AC | sc-376973 AC | 500 µg/ml, 25% agarose | $416.00 | |||
R2/p53R2 Antibody (F-9) HRP | sc-376973 HRP | 200 µg/ml | $316.00 | |||
R2/p53R2 Antibody (F-9) FITC | sc-376973 FITC | 200 µg/ml | $330.00 | |||
R2/p53R2 Antibody (F-9) PE | sc-376973 PE | 200 µg/ml | $343.00 | |||
R2/p53R2 Antibody (F-9) Alexa Fluor® 488 | sc-376973 AF488 | 200 µg/ml | $357.00 | |||
R2/p53R2 Antibody (F-9) Alexa Fluor® 546 | sc-376973 AF546 | 200 µg/ml | $357.00 | |||
R2/p53R2 Antibody (F-9) Alexa Fluor® 594 | sc-376973 AF594 | 200 µg/ml | $357.00 | |||
R2/p53R2 Antibody (F-9) Alexa Fluor® 647 | sc-376973 AF647 | 200 µg/ml | $357.00 | |||
R2/p53R2 Antibody (F-9) Alexa Fluor® 680 | sc-376973 AF680 | 200 µg/ml | $357.00 | |||
R2/p53R2 Antibody (F-9) Alexa Fluor® 790 | sc-376973 AF790 | 200 µg/ml | $357.00 |