QDPR Antibody (B-1): sc-376218

QDPR Antibody (B-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects QDPR of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). QDPR monoclonal antibody (B-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. QDPR, also known as dihydropteridine reductase (DHPR) or PKU2, is a crucial enzyme belonging to the short-chain dehydrogenases/reductase (SDR) family, functioning as a homodimer. QDPR plays a vital role in recycling tetrahydrobiopterin (BH4), an essential cofactor necessary for hydroxylation of aromatic amino acids such as tryptophan, tyrosine, and phenylalanine. QDPR catalyzes BH4 regeneration from quinonoid dihydrobiopterin (qBH2), which is produced during these hydroxylation reactions. Mutations in QDPR can lead to phenylketonuria II (PK2), a disorder characterized by depletion of neurotransmitters like dopamine, epinephrine, and serotonin due to impaired BH4 recycling. PK2 symptoms include hyperphenylalaninemia, axial hypotonia, truncal hypertonia, microcephaly, and abnormal thermogenesis, highlighting QDPR′s importance in maintaining neurological health and metabolic balance.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

QDPR Antibody (B-1) References:

1. Molecular analysis of 16 Turkish families with DHPR deficiency using denaturing gradient gel electrophoresis (DGGE).  |  Romstad, A., et al. 2000. Hum Genet. 107: 546-53. PMID: 11153907
2. Evaluation of a fetus at risk for dihydropteridine reductase deficiency by direct mutation analysis using denaturing gradient gel electrophoresis.  |  Kalkanoglu, HS., et al. 2001. Prenat Diagn. 21: 868-70. PMID: 11746132
3. Mutations in the BH4-metabolizing genes GTP cyclohydrolase I, 6-pyruvoyl-tetrahydropterin synthase, sepiapterin reductase, carbinolamine-4a-dehydratase, and dihydropteridine reductase.  |  Thöny, B. and Blau, N. 2006. Hum Mutat. 27: 870-8. PMID: 16917893
4. Molecular genetics of tetrahydrobiopterin (BH4) deficiency in the Maltese population.  |  Farrugia, R., et al. 2007. Mol Genet Metab. 90: 277-83. PMID: 17188538
5. Physical and genetic localization of quinonoid dihydropteridine reductase gene (QDPR) on short arm of chromosome 4.  |  MacDonald, ME., et al. 1987. Somat Cell Mol Genet. 13: 569-74. PMID: 2889272
6. Localization of the human dihydropteridine reductase gene to band p15.3 of chromosome 4 by in situ hybridization.  |  Brown, RM. and Dahl, HH. 1987. Genomics. 1: 67-70. PMID: 3666748
7. Two new mutations in the dihydropteridine reductase gene in patients with tetrahydrobiopterin deficiency.  |  Dianzani, I., et al. 1993. J Med Genet. 30: 465-9. PMID: 8326489
8. Dihydropteridine reductase deficiency: physical structure of the QDPR gene, identification of two new mutations and genotype-phenotype correlations.  |  Dianzani, I., et al. 1998. Hum Mutat. 12: 267-73. PMID: 9744478

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-QDPR Antibody (B-1) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-QDPR Antibody (B-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

QDPR Antibody (B-1) Specifications

Alternate Product Name: QDPR

Product Clone Name: B-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 11-244

Epitope Target: QDPR

Epitope Species: human

Product Reactivity/Detection: QDPR

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for QDPR Antibody (B-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin