PXR Antibody (H-11): sc-48340
- PXR Antibody (H-11) is a mouse monoclonal IgG2b κ, cited in 43 publications, provided at 200 µg/ml
- raised against amino acids 101-260 of PXR of human origin
- PXR Antibody (H-11) is recommended for detection of PXR.1 and PXR.2 of human origin by WB, IP, IF and ELISA
- Anti-PXR Antibody (H-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- TransCruz reagent for Gel Supershift and ChIP applications (sc-48340 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP and m-IgG2b BP-HRP are the preferred secondary detection reagents for PXR Antibody (H-11) for WB applications. These reagents are now offered in bundles with PXR Antibody (H-11) (see ordering information below).
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SEE ALSO...
PXR Antibody (H-11) is a mouse monoclonal IgG2b kappa light chain antibody that detects PXR in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PXR (H-11) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The Pregnane X Receptor (PXR) plays a crucial role in the regulation of gene expression by acting as a sensor for a wide range of endogenous and exogenous compounds, including steroids and drugs. Located primarily in the nucleus, PXR functions as a transcription factor that, upon binding to ligands, forms a heterodimer with retinoid X receptor (RXR) and subsequently binds to specific DNA sequences to modulate the expression of target genes involved in drug metabolism and transport. This localization enables PXR to directly influence cellular response to various substances, thereby playing a significant role in pharmacogenomics and the body′s ability to process medications. PXR exists in two isoforms, PXR.1 and PXR.2, which may have distinct regulatory functions, further emphasizing PXR′s importance in mediating the effects of synthetic glucocorticoids and other compounds that do not operate through classical glucocorticoid receptor pathways.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PXR Antibody (H-11) | sc-48340 | 200 µg/ml | $322.00 | |||
PXR Antibody (H-11): m-IgG Fc BP-HRP Bundle | sc-525559 | 200 µg Ab; 10 µg BP | $361.00 | |||
PXR Antibody (H-11): m-IgG2b BP-HRP Bundle | sc-549582 | 200 µg Ab; 10 µg BP | $361.00 | |||
PXR Antibody (H-11) X | sc-48340 X | 200 µg/0.1 ml | $322.00 | |||
PXR Antibody (H-11) AC | sc-48340 AC | 500 µg/ml, 25% agarose | $424.00 | |||
PXR Antibody (H-11) HRP | sc-48340 HRP | 200 µg/ml | $322.00 | |||
PXR Antibody (H-11) FITC | sc-48340 FITC | 200 µg/ml | $336.00 | |||
PXR Antibody (H-11) PE | sc-48340 PE | 200 µg/ml | $349.00 | |||
PXR Antibody (H-11) Alexa Fluor® 488 | sc-48340 AF488 | 200 µg/ml | $364.00 | |||
PXR Antibody (H-11) Alexa Fluor® 546 | sc-48340 AF546 | 200 µg/ml | $364.00 | |||
PXR Antibody (H-11) Alexa Fluor® 594 | sc-48340 AF594 | 200 µg/ml | $364.00 | |||
PXR Antibody (H-11) Alexa Fluor® 647 | sc-48340 AF647 | 200 µg/ml | $364.00 | |||
PXR Antibody (H-11) Alexa Fluor® 680 | sc-48340 AF680 | 200 µg/ml | $364.00 | |||
PXR Antibody (H-11) Alexa Fluor® 790 | sc-48340 AF790 | 200 µg/ml | $364.00 |