PXR Antibody (H-11) is a mouse monoclonal IgG2b (kappa light chain) provided at 200 µg/ml
raised against amino acids 101-260 of PXR of human origin
PXR Antibody (H-11) is recommended for detection of PXR.1 and PXR.2 of human origin by WB, IP, IF and ELISA
PXR Antibody (H-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
TransCruz reagent for Gel Supershift and ChIP applications (sc-48340 X, 200 µg/0.1 ml)
See m-IgGκ BP-HRP (mouse IgGκ binding protein-HRP), our highly recommended recombinant alternative to conventional secondary anti-mouse IgG reagents.
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of PXR (H-11): sc-48340.
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
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Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
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Labware ships FedEx Ground free of charge to the contiguous US
Steroid hormones function as signaling molecules by diffusing into cells and interacting with specific intracellular receptors to regulate gene expression. This superfamily of receptors includes both steroid and nonsteroid receptors. Like many nonsteroid hormone receptors, PXR (Pregnane X Receptor) binds as a heterodimer with RXR to a DNA sequence typical of a nonsteroid hormone receptor; however, PXR is activated by several steroids, such as naturally occurring pregnanes and synthetic glucocorticoids and anti- glucocorticoids. PXR exists as two alternatively spliced isoforms, PXR.1 and PXR.2. PXR is thought to define a novel steroid hormone signaling pathway that may account for some of the effects of synthetic glucocorticoids and antiglucocorticoids that are not mediated through the classical glucocorticoid receptor signaling pathway.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
hi All of you,
Do you know if you this antibody could detect the dimer of hPXR ?
Asked by: Alessandro G
Thank you for your question. Please Contact our Technical Service for additional information regarding this antibody.
Answered by: SCBT Heidelberg Support
Date published: 2018-12-22
When should the TransCruz reagent sc-48340 X be used instead of the standard form sc-48340?
Asked by: jerojero
Thank you for your question. We recommend using the TransCruz reagent form when performing ChIP or GelShift assays. This form can also be used in other applications such as Western Blot or IHC, but the dilution should be adjusted by a factor of 10 to account for the higher original concentration.
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