PU.1/Spi1 Antibody (A-7): sc-365208
- PU.1/Spi1 Antibody (A-7) is a mouse monoclonal IgG1 κ, cited in 7 publications, provided at 200 µg/ml
- raised against amino acids 1-135 of PU.1 of human origin
- recommended for detection of PU.1 of human origin by WB, IP, IF, IHC(P) and ELISA
- TransCruz reagent for ChIP application (sc-365208 X, 200 µg/0.1 ml)
- See PU.1/Spi1 (C-3): sc-390405 for PU.1/Spi1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for PU.1/Spi1 Antibody (A-7) for WB and IHC(P) applications. These reagents are now offered in bundles with PU.1/Spi1 Antibody (A-7) (see ordering information below).
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SEE ALSO...
PU.1 Antibody (A-7) is a mouse monoclonal IgG1 antibody that detects PU.1 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). PU.1 is a critical transcription factor belonging to the Ets family, playing a vital role in the regulation of gene expression during lymphoid development and immune response. PU.1 is primarily located in the nucleus of hematopoietic cells, where PU.1 binds to specific DNA sequences to activate genes essential for B cell differentiation and function. Nuclear localization of PU.1 enables interaction with other transcription factors and co-regulators, orchestrating a complex network of gene expression that influences the development of various immune cell types, including B cells and T cells. PU.1 transactivates multiple genes involved in B cell signaling, such as CD72, CD20, and Bruton′s tyrosine kinase (Btk), which are essential for B cell maturation and function. Precise regulation of PU.1 expression and activity maintains immune homeostasis, and dysregulation can lead to hematological malignancies. As a key regulator in immune cell development, anti-PU.1 antibody (A-7) serves as an invaluable tool for researchers studying immune responses and related disorders.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PU.1/Spi1 Antibody (A-7) | sc-365208 | 200 µg/ml | $322.00 | |||
PU.1/Spi1 Antibody (A-7): m-IgG Fc BP-HRP Bundle | sc-540317 | 200 µg Ab; 10 µg BP | $361.00 | |||
PU.1/Spi1 Antibody (A-7): m-IgG1 BP-HRP Bundle | sc-542038 | 200 µg Ab; 20 µg BP | $361.00 | |||
PU.1/Spi1 Antibody (A-7) X | sc-365208 X | 200 µg/0.1 ml | $322.00 |