PTTG Antibody (H-3): sc-514984
- PTTG Antibody (H-3) is a mouse monoclonal IgG3 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 154-183 near the C-terminus of PTTG of mouse origin
- recommended for detection of PTTG of mouse, rat and human origin by WB, IP, IF and ELISA
- See PTTG (DCS-280): sc-56207 for PTTG antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG3 BP-HRP is the preferred secondary detection reagent for PTTG Antibody (H-3) for WB applications. This reagent is now offered in a bundle with PTTG Antibody (H-3) (see ordering information below).
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SEE ALSO...
PTTG Antibody (H-3) is a mouse monoclonal IgG3 antibody that detects pituitary tumor transforming gene (PTTG) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PTTG plays a significant role in cell cycle regulation, particularly in sister chromatid separation during mitosis. PTTG regulates separin Esp1, which promotes chromatid separation and overcomes cohesive forces holding sister chromatids together, making PTTG essential for genomic stability. Dysregulation of PTTG can lead to chromosome instability, a hallmark of many cancers, highlighting PTTG′s importance in tumorigenesis. PTTG is predominantly expressed in the cytoplasm, with partial nuclear localization, and shows high expression in thymus, testis, placenta, and Jurkat cells. PTTG′s basic amino-terminal and acidic carboxy-terminal domains contribute to transactivator function when fused to DNA binding domains, emphasizing PTTG′s role in cellular processes. anti-PTTG antibody (H-3) serves as an essential tool for researchers studying cell cycle dynamics and cancer biology, providing reliable detection and characterization of PTTG.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PTTG Antibody (H-3) | sc-514984 | 200 µg/ml | $316.00 | |||
PTTG Antibody (H-3): m-IgG3 BP-HRP Bundle | sc-550526 | 200 µg Ab; 40 µg BP | $354.00 | |||
PTTG (H-3) Neutralizing Peptide | sc-514984 P | 100 µg/0.5 ml | $68.00 |