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PTTG Antibody (3F313) is a mouse monoclonal IgG2a antibody that detects pituitary tumor transforming gene (PTTG) in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). PTTG plays a crucial role in cell cycle regulation by acting as an anaphase inhibitor, specifically regulating separin Esp1, which is essential for chromatid separation during mitosis. This function helps ensure proper chromosome segregation, thereby preventing chromosomal instability, a hallmark of many cancers. PTTG expression has been observed in various human tissues, including thymus, testis, and placenta, with primary localization in cytoplasm and partial presence in nucleus, underscoring PTTG′s importance in cellular processes. PTTG′s interaction with other proteins involved in cell cycle regulation highlights anti-PTTG antibody (3F313) as an invaluable tool for scientists studying tumorigenesis and chromosomal dynamics.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PTTG Antibody (3F313) | sc-71947 | 200 µg/ml | $316.00 | |||
PTTG Antibody (3F313): m-IgG2a BP-HRP Bundle | sc-546005 | 200 µg Ab; 10 µg BP | $354.00 |