PTPS Antibody (AT2B2): sc-517423

PTPS Antibody (AT2B2) is a mouse monoclonal IgG2b antibody that detects PTPS in mouse, rat, and human samples through applications such as western blotting (WB), immunofluorescence (IF), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). PTPS, or 6-pyruvoyltetrahydropterin synthase, plays a critical role in the biosynthesis of tetrahydrobiopterin (BH4), an essential cofactor for various hydroxylases involved in the degradation of phenylalanine and the synthesis of neurotransmitters like catecholamines and serotonin. The proper functioning of PTPS is vital, as BH4 deficiency can lead to serious metabolic disorders, including hyperphenylalaninemia and depletion of monoamine neurotransmitters, which are crucial for normal brain function. The enzyme′s active site features a unique arrangement of residues, including a pterin-anchoring glutamic acid and a catalytic triad composed of cysteine, aspartate, and histidine, which are essential for enzymatic activity. Additionally, the presence of post-translational modifications, such as phosphorylation of Ser 19 by cGMP-dependent protein kinase type II, is important for regulating PTPS activity, highlighting the intricate control mechanisms that govern function in cellular metabolism. Anti-PTPS antibody (AT2B2) is an invaluable tool for researchers studying the biochemical pathways involving BH4 and its implications in various physiological and pathological conditions.

The preferred PTPS antibody is PTPS Antibody (D-8): sc-514628.