PTPε Antibody (G-2): sc-515692

PTPε Antibody (G-2) is a mouse monoclonal IgG3 antibody that detects PTPε in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-PTPε antibody (G-2) is available in a non-conjugated form, allowing for versatile experimental use. Protein tyrosine phosphatases (PTPs) like PTPε are crucial for regulating various cellular processes, including cell growth, differentiation, and signaling pathways. PTPε is primarily located in the cell membrane, where PTPε plays a significant role in modulating receptor tyrosine kinase signaling, which is essential for proper cellular communication and response to external stimuli. PTPε localization at the membrane allows direct interaction with various signaling molecules, thereby influencing pathways that govern cell proliferation and survival. PTPε dysregulation has been implicated in several diseases, including cancer, making PTPε a vital target for therapeutic intervention and research. Understanding PTPε function and location is important for elucidating PTPε role in cellular signaling and potential as a biomarker or therapeutic target in various pathologies.

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PTPε Antibody (G-2) References:

1. Complex-type asparagine-linked oligosaccharides on phosphacan and protein-tyrosine phosphatase-zeta/beta mediate their binding to neural cell adhesion molecules and tenascin.  |  Milev, P., et al. 1995. J Biol Chem. 270: 24650-3. PMID: 7559574
2. Protein-tyrosine phosphatase epsilon. An isoform specifically expressed in mouse mammary tumors initiated by v-Ha-ras OR neu.  |  Elson, A. and Leder, P. 1995. J Biol Chem. 270: 26116-22. PMID: 7592814
3. Receptor protein tyrosine phosphatase PTPmu associates with cadherins and catenins in vivo.  |  Brady-Kalnay, SM., et al. 1995. J Cell Biol. 130: 977-86. PMID: 7642713
4. Increased abundance of the receptor-type protein-tyrosine phosphatase LAR accounts for the elevated insulin receptor dephosphorylating activity in adipose tissue of obese human subjects.  |  Ahmad, F., et al. 1995. J Clin Invest. 95: 2806-12. PMID: 7769120
5. Homophilic interactions mediated by receptor tyrosine phosphatases mu and kappa. A critical role for the novel extracellular MAM domain.  |  Zondag, GC., et al. 1995. J Biol Chem. 270: 14247-50. PMID: 7782276
6. Stimulation of receptor protein-tyrosine phosphatase alpha activity and phosphorylation by phorbol ester.  |  den Hertog, J., et al. 1995. Cell Growth Differ. 6: 303-7. PMID: 7794797

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PTPε Antibody (G-2) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-PTPε Antibody (G-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PTPε Antibody (G-2) Specifications

Alternate Product Name: PTPε

Product Clone Name: G-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃

Amino Acids: 678-699

Epitope Target: PTPε

Epitope Species: human

Product Reactivity/Detection: PTPε and, to a lesser extent, PTPα

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₃ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for PTPε Antibody (G-2): N/A