PSMD4 Antibody (F-6): sc-398033
- PSMD4 Antibody (F-6) is a mouse monoclonal IgG2a κ PSMD4 antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 1-300 mapping at the N-terminus of PSMD4 of human origin
- PSMD4 Antibody (F-6) is recommended for detection of PSMD4 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- Anti-PSMD4 Antibody (F-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for PSMD4 Antibody (F-6) for WB and IHC(P) applications. These reagents are now offered in bundles with PSMD4 Antibody (F-6) (see ordering information below).
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PSMD4 Antibody (F-6) is a mouse monoclonal IgG2a kappa light chain antibody that detects PSMD4 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-PSMD4 antibody (F-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PSMD4 plays a crucial role in the ubiquitin-proteasome pathway, which is essential for maintaining cellular homeostasis by regulating protein degradation. This pathway is vital for removing damaged or misfolded proteins, thus preventing cellular stress and potential disease states. PSMD4, also known as S5a, is involved in recognizing polyubiquitinated substrates, facilitating their entry into the 26S proteasome for degradation. PSMD4 is expressed in various tissues and is particularly important during specific developmental stages, where PSMD4 may contribute to the selective degradation of proteins that are critical for embryonic development. PSMD4′s ability to interact with other components of the proteasome, such as Rpn10D and Rpn10E, highlights PSMD4′s significance in both general proteolytic functions and specialized roles in early development, making PSMD4 a key player in cellular regulation and development.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PSMD4 Antibody (F-6) References:
- The 26S proteasome: a molecular machine designed for controlled proteolysis. | Voges, D., et al. 1999. Annu Rev Biochem. 68: 1015-68. PMID: 10872471
- Developmentally regulated, alternative splicing of the Rpn10 gene generates multiple forms of 26S proteasomes. | Kawahara, H., et al. 2000. EMBO J. 19: 4144-53. PMID: 10921894
- Purification and characterization of the antisecretory factor: a protein in the central nervous system and in the gut which inhibits intestinal hypersecretion induced by cholera toxin. | Lönnroth, I. and Lange, S. 1986. Biochim Biophys Acta. 883: 138-44. PMID: 3524692
- Molecular cloning and expression of a pituitary gland protein modulating intestinal fluid secretion. | Johansson, E., et al. 1995. J Biol Chem. 270: 20615-20. PMID: 7657640
- Structure and functions of the 20S and 26S proteasomes. | Coux, O., et al. 1996. Annu Rev Biochem. 65: 801-47. PMID: 8811196
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PSMD4 Antibody (F-6) | sc-398033 | 200 µg/ml | $322.00 | |||
PSMD4 Antibody (F-6): m-IgG Fc BP-HRP Bundle | sc-530673 | 200 µg Ab; 10 µg BP | $361.00 | |||
PSMD4 Antibody (F-6): m-IgGκ BP-HRP Bundle | sc-524193 | 200 µg Ab, 40 µg BP | $361.00 | |||
PSMD4 Antibody (F-6): m-IgG2a BP-HRP Bundle | sc-547555 | 200 µg Ab; 10 µg BP | $361.00 | |||
PSMD4 Antibody (F-6) AC | sc-398033 AC | 500 µg/ml, 25% agarose | $424.00 | |||
PSMD4 Antibody (F-6) HRP | sc-398033 HRP | 200 µg/ml | $322.00 | |||
PSMD4 Antibody (F-6) FITC | sc-398033 FITC | 200 µg/ml | $336.00 | |||
PSMD4 Antibody (F-6) PE | sc-398033 PE | 200 µg/ml | $349.00 | |||
PSMD4 Antibody (F-6) Alexa Fluor® 488 | sc-398033 AF488 | 200 µg/ml | $364.00 | |||
PSMD4 Antibody (F-6) Alexa Fluor® 546 | sc-398033 AF546 | 200 µg/ml | $364.00 | |||
PSMD4 Antibody (F-6) Alexa Fluor® 594 | sc-398033 AF594 | 200 µg/ml | $364.00 | |||
PSMD4 Antibody (F-6) Alexa Fluor® 647 | sc-398033 AF647 | 200 µg/ml | $364.00 | |||
PSMD4 Antibody (F-6) Alexa Fluor® 680 | sc-398033 AF680 | 200 µg/ml | $364.00 | |||
PSMD4 Antibody (F-6) Alexa Fluor® 790 | sc-398033 AF790 | 200 µg/ml | $364.00 |