PSMD3 Antibody (G-1): sc-393588
- PSMD3 Antibody (G-1) is a mouse monoclonal IgG2b κ PSMD3 antibody, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 340-528 mapping near the C-terminus of PSMD3 of human origin
- PSMD3 Antibody (G-1) is recommended for detection of PSMD3 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-PSMD3 Antibody (G-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for PSMD3 Antibody (G-1) for WB and IHC(P) applications. These reagents are now offered in bundles with PSMD3 Antibody (G-1) (see ordering information below).
PSMD3 Antibody (G-1) is a mouse monoclonal IgG2b kappa light chain antibody that detects PSMD3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). PSMD3 (G-1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PSMD3, also known as proteasome 26S subunit, non-ATPase, 3, plays a crucial role in regulating the 26S proteasome, a vital complex responsible for selective degradation of ubiquitinated proteins within eukaryotic cells. This process is essential for maintaining cellular homeostasis, regulating cell cycle, and modulating various signaling pathways. PSMD3, consisting of 534 amino acids and containing a PCI domain, is encoded by a gene located on human chromosome 17, a region encompassing over 2.5% of the human genome and responsible for encoding more than 1,200 genes. PSMD3′s interaction with other regulatory subunits of the 26S proteasome is critical for recognition and unfolding of ubiquitinated substrates, facilitating their degradation and ensuring proper turnover of proteins that could otherwise accumulate and disrupt cellular function.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PSMD3 Antibody (G-1) References:
- [Investigation on NB4 cell responses to realgar by cDNA microarray]. | Wang, HY. and Liu, SX. 2002. Zhongguo Zhong Yao Za Zhi. 27: 600-4. PMID: 12776498
- Gene expression profile changes in NB4 cells induced by realgar. | Wang, H., et al. 2003. Chin Med J (Engl). 116: 1074-7. PMID: 12890387
- Mass spectrometric analysis of expression of ATPase subunits encoded by duplicated genes in the 19S regulatory particle of rice 26S proteasome. | Shibahara, T., et al. 2004. Arch Biochem Biophys. 421: 34-41. PMID: 14678782
- Post-translationally modified S12, absent in transformed breast epithelial cells, is not associated with the 26S proteasome and is induced by proteasome inhibitor. | Thompson, HG., et al. 2004. Int J Cancer. 111: 338-47. PMID: 15221960
- Mapping of the CCK, PSMC2, PSMC4, PSMD1, CPB1 and PSPH genes in cattle. | Guo, H., et al. 2006. Anim Genet. 37: 73-5. PMID: 16441302
- Effects of tumor necrosis factor-alpha on the 26S proteasome and 19S regulator in skeletal muscle of severely scalded mice. | Tan, Y., et al. 2006. J Burn Care Res. 27: 226-33. PMID: 16566573
- Prostaglandin J2 alters pro-survival and pro-death gene expression patterns and 26 S proteasome assembly in human neuroblastoma cells. | Wang, Z., et al. 2006. J Biol Chem. 281: 21377-21386. PMID: 16737963
- Over-expression of genes and proteins of ubiquitin specific peptidases (USPs) and proteasome subunits (PSs) in breast cancer tissue observed by the methods of RFDD-PCR and proteomics. | Deng, S., et al. 2007. Breast Cancer Res Treat. 104: 21-30. PMID: 17004105
- CDNA cloning of p112, the largest regulatory subunit of the human 26s proteasome, and functional analysis of its yeast homologue, sen3p. | Yokota, K., et al. 1996. Mol Biol Cell. 7: 853-70. PMID: 8816993
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PSMD3 Antibody (G-1) | sc-393588 | 200 µg/ml | $322.00 | |||
PSMD3 Antibody (G-1): m-IgG Fc BP-HRP Bundle | sc-530512 | 200 µg Ab; 10 µg BP | $361.00 | |||
PSMD3 Antibody (G-1): m-IgGκ BP-HRP Bundle | sc-524015 | 200 µg Ab, 40 µg BP | $361.00 | |||
PSMD3 Antibody (G-1): m-IgG2b BP-HRP Bundle | sc-550195 | 200 µg Ab; 10 µg BP | $361.00 | |||
PSMD3 Antibody (G-1) AC | sc-393588 AC | 500 µg/ml, 25% agarose | $424.00 | |||
PSMD3 Antibody (G-1) HRP | sc-393588 HRP | 200 µg/ml | $322.00 | |||
PSMD3 Antibody (G-1) FITC | sc-393588 FITC | 200 µg/ml | $336.00 | |||
PSMD3 Antibody (G-1) PE | sc-393588 PE | 200 µg/ml | $349.00 | |||
PSMD3 Antibody (G-1) Alexa Fluor® 488 | sc-393588 AF488 | 200 µg/ml | $364.00 | |||
PSMD3 Antibody (G-1) Alexa Fluor® 546 | sc-393588 AF546 | 200 µg/ml | $364.00 | |||
PSMD3 Antibody (G-1) Alexa Fluor® 594 | sc-393588 AF594 | 200 µg/ml | $364.00 | |||
PSMD3 Antibody (G-1) Alexa Fluor® 647 | sc-393588 AF647 | 200 µg/ml | $364.00 | |||
PSMD3 Antibody (G-1) Alexa Fluor® 680 | sc-393588 AF680 | 200 µg/ml | $364.00 | |||
PSMD3 Antibody (G-1) Alexa Fluor® 790 | sc-393588 AF790 | 200 µg/ml | $364.00 |