PSMD11 Antibody (AT2C7): sc-517422

PSMD11 Antibody (AT2C7) is a mouse monoclonal IgG2b kappa light chain antibody that detects PSMD11 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Anti-PSMD11 antibody (AT2C7) is available in a non-conjugated form, providing flexibility for various experimental needs. PSMD11, also known as S9, Rpn6, or p44.5, is a crucial regulatory subunit of the 26S proteasome, a complex responsible for the selective degradation of ubiquitinated proteins, which is vital for maintaining cellular homeostasis and regulating various cellular processes. PSMD11 consists of 422 amino acids and features a PCI domain, which is essential for its role in the ATP-dependent degradation pathway. Proper functioning of PSMD11 ensures that damaged or misfolded proteins are efficiently removed from the cell, preventing potential toxic accumulation that could lead to cellular dysfunction or disease. The gene encoding PSMD11 is located on human chromosome 17, a region that encompasses over 2.5% of the human genome and is known to encode more than 1,200 genes, highlighting PSMD11′s importance in cellular regulation and proteostasis.

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PSMD11 Antibody (AT2C7) References:

1. S9, a 19 S proteasome subunit interacting with ubiquitinated NF-kappaB2/p100.  |  Fong, A., et al. 2002. J Biol Chem. 277: 40697-702. PMID: 12185077
2. Demonstration that a human 26S proteolytic complex consists of a proteasome and multiple associated protein components and hydrolyzes ATP and ubiquitin-ligated proteins by closely linked mechanisms.  |  Kanayama, HO., et al. 1992. Eur J Biochem. 206: 567-78. PMID: 1317798
3. Alterations in mRNA expression and protein products following spinal cord injury in humans.  |  Urso, ML., et al. 2007. J Physiol. 579: 877-92. PMID: 17218363
4. Increased proteasome activity in human embryonic stem cells is regulated by PSMD11.  |  Vilchez, D., et al. 2012. Nature. 489: 304-8. PMID: 22972301
5. cAMP-induced phosphorylation of 26S proteasomes on Rpn6/PSMD11 enhances their activity and the degradation of misfolded proteins.  |  Lokireddy, S., et al. 2015. Proc Natl Acad Sci U S A. 112: E7176-85. PMID: 26669444
6. Homoharringtonine could induce quick protein synthesis of PSMD11 through activating MEK1/ERK1/2 signaling pathway in pancreatic cancer cells.  |  Wang, L., et al. 2018. J Cell Biochem. 119: 6644-6656. PMID: 29665121
7. Long noncoding RNA Nespas inhibits apoptosis of epileptiform hippocampal neurons by inhibiting the PI3K/Akt/mTOR pathway.  |  Feng, H., et al. 2021. Exp Cell Res. 398: 112384. PMID: 33212147
8. S14-Phosphorylated RPN6 Mediates Proteasome Activation by PKA and Alleviates Proteinopathy.  |  Yang, L., et al. 2023. Circ Res. 133: 572-587. PMID: 37641975
9. Promoting proteostasis by cAMP/PKA and cGMP/PKG.  |  Ahammed, MS. and Wang, X. 2024. Trends Mol Med.. PMID: 39477759
10. Structure and functions of the 20S and 26S proteasomes.  |  Coux, O., et al. 1996. Annu Rev Biochem. 65: 801-47. PMID: 8811196
11. Molecular cloning and expression of subunit 9 of the 26S proteasome.  |  Hoffman, L. and Rechsteiner, M. 1997. FEBS Lett. 404: 179-84. PMID: 9119060
12. cDNA cloning and functional analysis of p44.5 and p55, two regulatory subunits of the 26S proteasome.  |  Saito, A., et al. 1997. Gene. 203: 241-50. PMID: 9426256

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PSMD11 Antibody (AT2C7) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-PSMD11 Antibody (AT2C7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PSMD11 Antibody (AT2C7) Specifications

Alternate Product Name: PSMD11

Product Clone Name: AT2C7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 1-422

Epitope Target: PSMD11

Epitope Species: human

Product Reactivity/Detection: PSMD11

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, FCM, ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide, 0.1% gelatin and 1% glycerol

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for PSMD11 Antibody (AT2C7): N/A