PSMC4 Antibody (G-4): sc-166115
- PSMC4 Antibody (G-4) is a mouse monoclonal IgG2b κ PSMC4 antibody, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 1-167 mapping at the N-terminus of PSMC4 of human origin
- PSMC4 Antibody (G-4) is recommended for detection of PSMC4 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-PSMC4 Antibody (G-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for PSMC4 Antibody (G-4) for WB and IHC(P) applications. These reagents are now offered in bundles with PSMC4 Antibody (G-4) (see ordering information below).
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PSMC4 Antibody (G-4) is a mouse monoclonal IgG2b kappa light chain antibody that detects PSMC4 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). PSMC4 (G-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PSMC4, also known as 26S protease regulatory subunit 6B, plays a crucial role in ATP-dependent degradation of ubiquitinated proteins, which is essential for maintaining cellular homeostasis and regulating various cellular processes, including cell cycle, apoptosis, and stress responses. PSMC4 functions as a key component of the 26S proteasome, a complex responsible for selective protein degradation, and proper function is vital for preventing accumulation of damaged or misfolded proteins that could lead to cellular dysfunction or disease. PSMC4 interacts with several regulatory proteins, including gankyrin, which is implicated in liver cancer, highlighting importance in both normal cellular function and disease states. Post-translational modifications of PSMC4, such as phosphorylation, further influence activity and interactions, making PSMC4 a significant target for research in cancer biology and therapeutic development.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PSMC4 Antibody (G-4) References:
- Mouse proteasomal ATPases Psmc3 and Psmc4: genomic organization and gene targeting. | Sakao, Y., et al. 2000. Genomics. 67: 1-7. PMID: 10945464
- Large-scale meta-analysis of cancer microarray data identifies common transcriptional profiles of neoplastic transformation and progression. | Rhodes, DR., et al. 2004. Proc Natl Acad Sci U S A. 101: 9309-14. PMID: 15184677
- Statistical modeling for selecting housekeeper genes. | Szabo, A., et al. 2004. Genome Biol. 5: R59. PMID: 15287981
- Tat-binding protein 7 is a subunit of the 26S protease. | Dubiel, W., et al. 1994. Biol Chem Hoppe Seyler. 375: 237-40. PMID: 8060531
- Chromosomal localization and immunological analysis of a family of human 26S proteasomal ATPases. | Tanahashi, N., et al. 1998. Biochem Biophys Res Commun. 243: 229-32. PMID: 9473509
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PSMC4 Antibody (G-4) | sc-166115 | 200 µg/ml | $316.00 | |||
PSMC4 Antibody (G-4): m-IgGκ BP-HRP Bundle | sc-521511 | 200 µg Ab, 40 µg BP | $354.00 | |||
PSMC4 Antibody (G-4): m-IgG2b BP-HRP Bundle | sc-548918 | 200 µg Ab; 10 µg BP | $354.00 | |||
PSMC4 Antibody (G-4) AC | sc-166115 AC | 500 µg/ml, 25% agarose | $416.00 | |||
PSMC4 Antibody (G-4) HRP | sc-166115 HRP | 200 µg/ml | $316.00 | |||
PSMC4 Antibody (G-4) FITC | sc-166115 FITC | 200 µg/ml | $330.00 | |||
PSMC4 Antibody (G-4) PE | sc-166115 PE | 200 µg/ml | $343.00 | |||
PSMC4 Antibody (G-4) Alexa Fluor® 488 | sc-166115 AF488 | 200 µg/ml | $357.00 | |||
PSMC4 Antibody (G-4) Alexa Fluor® 546 | sc-166115 AF546 | 200 µg/ml | $357.00 | |||
PSMC4 Antibody (G-4) Alexa Fluor® 594 | sc-166115 AF594 | 200 µg/ml | $357.00 | |||
PSMC4 Antibody (G-4) Alexa Fluor® 647 | sc-166115 AF647 | 200 µg/ml | $357.00 | |||
PSMC4 Antibody (G-4) Alexa Fluor® 680 | sc-166115 AF680 | 200 µg/ml | $357.00 | |||
PSMC4 Antibody (G-4) Alexa Fluor® 790 | sc-166115 AF790 | 200 µg/ml | $357.00 |