PSMC2 Antibody (C-1): sc-166972
- PSMC2 Antibody (C-1) is a mouse monoclonal IgG2a κ PSMC2 antibody, cited in 11 publications, provided at 200 µg/ml
- raised against amino acids 29-122 mapping near the N-terminus of PSMC2 of human origin
- PSMC2 Antibody (C-1) is recommended for detection of PSMC2 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-PSMC2 Antibody (C-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for PSMC2 Antibody (C-1) for WB applications. These reagents are now offered in bundles with PSMC2 Antibody (C-1) (see ordering information below).
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PSMC2 Antibody (C-1) is a mouse monoclonal IgG2a kappa light chain antibody that detects PSMC2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PSMC2 (C-1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PSMC2 protein, also known as Proteasome 26S subunit ATPase 2, is a crucial component of the 26S proteasome, a multi-subunit complex responsible for the selective degradation of ubiquitinated proteins, which is vital for maintaining cellular homeostasis and regulating various cellular processes. PSMC2, consisting of 433 amino acids, is localized in both the nucleus and cytoplasm, where PSMC2 functions as a chaperone-like subunit of the 19S regulatory complex, facilitating the unfolding and translocation of substrates into the proteolytic core of the proteasome. PSMC2′s role is particularly important in the context of cellular stress responses and the regulation of protein turnover, as PSMC2 ensures that damaged or misfolded proteins are efficiently removed from the cell. Additionally, PSMC2 has been implicated in interactions with several basal transcription factors, suggesting a potential role in transcriptional regulation, particularly in response to viral infections such as HIV-1, where PSMC2 can enhance the transactivation mediated by the viral protein Tat.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PSMC2 Antibody (C-1) References:
- Tissue and cell distribution of a mammalian proteasomal ATPase, MSS1, and its complex formation with the basal transcription factors. | Yanagi, S., et al. 2000. Biochem Biophys Res Commun. 279: 568-73. PMID: 11118327
- Structural determinants for the binding of ubiquitin-like domains to the proteasome. | Mueller, TD. and Feigon, J. 2003. EMBO J. 22: 4634-45. PMID: 12970176
- New human gene encoding a positive modulator of HIV Tat-mediated transactivation. | Shibuya, H., et al. 1992. Nature. 357: 700-2. PMID: 1377363
- Induction of APOBEC3G ubiquitination and degradation by an HIV-1 Vif-Cul5-SCF complex. | Yu, X., et al. 2003. Science. 302: 1056-60. PMID: 14564014
- The Vif protein of HIV triggers degradation of the human antiretroviral DNA deaminase APOBEC3G. | Conticello, SG., et al. 2003. Curr Biol. 13: 2009-13. PMID: 14614829
- Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation. | Seibenhener, ML., et al. 2004. Mol Cell Biol. 24: 8055-68. PMID: 15340068
- Proteasomal ATPase-associated factor 1 negatively regulates proteasome activity by interacting with proteasomal ATPases. | Park, Y., et al. 2005. Mol Cell Biol. 25: 3842-53. PMID: 15831487
- Effects of tumor necrosis factor-alpha on the 26S proteasome and 19S regulator in skeletal muscle of severely scalded mice. | Tan, Y., et al. 2006. J Burn Care Res. 27: 226-33. PMID: 16566573
- HEC binds to the seventh regulatory subunit of the 26 S proteasome and modulates the proteolysis of mitotic cyclins. | Chen, Y., et al. 1997. J Biol Chem. 272: 24081-7. PMID: 9295362
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PSMC2 Antibody (C-1) | sc-166972 | 200 µg/ml | $322.00 | |||
PSMC2 Antibody (C-1): m-IgG Fc BP-HRP Bundle | sc-529096 | 200 µg Ab; 10 µg BP | $361.00 | |||
PSMC2 Antibody (C-1): m-IgGκ BP-HRP Bundle | sc-521813 | 200 µg Ab, 40 µg BP | $361.00 | |||
PSMC2 Antibody (C-1): m-IgG2a BP-HRP Bundle | sc-547260 | 200 µg Ab; 10 µg BP | $361.00 | |||
PSMC2 Antibody (C-1) AC | sc-166972 AC | 500 µg/ml, 25% agarose | $424.00 | |||
PSMC2 Antibody (C-1) HRP | sc-166972 HRP | 200 µg/ml | $322.00 | |||
PSMC2 Antibody (C-1) FITC | sc-166972 FITC | 200 µg/ml | $336.00 | |||
PSMC2 Antibody (C-1) PE | sc-166972 PE | 200 µg/ml | $349.00 | |||
PSMC2 Antibody (C-1) Alexa Fluor® 488 | sc-166972 AF488 | 200 µg/ml | $364.00 | |||
PSMC2 Antibody (C-1) Alexa Fluor® 546 | sc-166972 AF546 | 200 µg/ml | $364.00 | |||
PSMC2 Antibody (C-1) Alexa Fluor® 594 | sc-166972 AF594 | 200 µg/ml | $364.00 | |||
PSMC2 Antibody (C-1) Alexa Fluor® 647 | sc-166972 AF647 | 200 µg/ml | $364.00 | |||
PSMC2 Antibody (C-1) Alexa Fluor® 680 | sc-166972 AF680 | 200 µg/ml | $364.00 | |||
PSMC2 Antibody (C-1) Alexa Fluor® 790 | sc-166972 AF790 | 200 µg/ml | $364.00 |