PSMB6 Antibody (B-6): sc-515919
- PSMB6 Antibody (B-6) is a mouse monoclonal IgG1 κ PSMB6 antibody, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 51-77 within an internal region of PSMB6 of human origin
- PSMB6 Antibody (B-6) is recommended for detection of PSMB6 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-PSMB6 Antibody (B-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for PSMB6 Antibody (B-6) for WB applications. These reagents are now offered in bundles with PSMB6 Antibody (B-6) (see ordering information below).
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PSMB6 Antibody (B-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects PSMB6 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PSMB6 (B-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PSMB6 protein, also known as proteasome (prosome, macropain) subunit, β type, 6, plays a crucial role in the proteolytic function of the 26S proteasome, which is essential for maintaining cellular homeostasis by degrading misfolded or damaged proteins. This process is vital for regulating various cellular processes, including cell cycle, apoptosis, and responses to oxidative stress. PSMB6 subunit is part of the 20S proteasome core, which is composed of a cylindrical structure made up of four stacked rings, with outer rings containing seven alpha subunits and inner rings containing seven beta subunits, where PSMB6 serves as one of the catalytic β subunits. Proper functioning of the proteasome is critical, as dysfunction can lead to accumulation of damaged proteins and has been implicated in various diseases, including cancer and neurodegenerative disorders. Anti-PSMB6 antibody (B-6) is an invaluable tool for researchers studying proteasome activity and its implications in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PSMB6 Antibody (B-6) References:
- Sequencing of amphioxus PSMB5/8 gene and phylogenetic position of agnathan sequences. | Takezaki, N., et al. 2002. Gene. 282: 179-87. PMID: 11814690
- Gene expression profile changes in NB4 cells induced by arsenic trioxide. | Wang, HY., et al. 2003. Acta Pharmacol Sin. 24: 646-50. PMID: 12852829
- IFN-alpha mediates the up-regulation of HLA class I on melanoma cells without switching proteasome to immunoproteasome. | Cangemi, G., et al. 2003. Int Immunol. 15: 1415-21. PMID: 14645150
- Molecular genetic analysis of the Idd4 locus implicates the IFN response in type 1 diabetes susceptibility in nonobese diabetic mice. | Ivakine, EA., et al. 2006. J Immunol. 176: 2976-90. PMID: 16493056
- Pharmacogenomics of the polyamine analog 3,8,13,18-tetraaza-10,11-[(E)-1,2-cyclopropyl]eicosane tetrahydrochloride, CGC-11093, in the colon adenocarcinoma cell line HCT1161. | Ignatenko, NA., et al. 2006. Technol Cancer Res Treat. 5: 553-64. PMID: 17121431
- Tissue specific increase of the catalytic subunits of the 26S proteasome by indirect antioxidant dithiolethione in mice: enhanced activity for degradation of abnormal protein. | Kwak, MK., et al. 2007. Life Sci. 80: 2411-20. PMID: 17521679
- Intermediates in the formation of mouse 20S proteasomes: implications for the assembly of precursor beta subunits. | Nandi, D., et al. 1997. EMBO J. 16: 5363-75. PMID: 9311996
- Reactions of [14C]-3,4-dichloroisocoumarin with subunits of pituitary and spleen multicatalytic proteinase complexes (proteasomes). | Orlowski, M., et al. 1997. Biochemistry. 36: 13946-53. PMID: 9374874
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PSMB6 Antibody (B-6) | sc-515919 | 200 µg/ml | $316.00 | |||
PSMB6 Antibody (B-6): m-IgG Fc BP-HRP Bundle | sc-528068 | 200 µg Ab; 10 µg BP | $354.00 | |||
PSMB6 Antibody (B-6): m-IgG1 BP-HRP Bundle | sc-533441 | 200 µg Ab; 20 µg BP | $354.00 | |||
PSMB6 Antibody (B-6) AC | sc-515919 AC | 500 µg/ml, 25% agarose | $416.00 | |||
PSMB6 Antibody (B-6) HRP | sc-515919 HRP | 200 µg/ml | $316.00 | |||
PSMB6 Antibody (B-6) FITC | sc-515919 FITC | 200 µg/ml | $330.00 | |||
PSMB6 Antibody (B-6) PE | sc-515919 PE | 200 µg/ml | $343.00 | |||
PSMB6 Antibody (B-6) Alexa Fluor® 488 | sc-515919 AF488 | 200 µg/ml | $357.00 | |||
PSMB6 Antibody (B-6) Alexa Fluor® 546 | sc-515919 AF546 | 200 µg/ml | $357.00 | |||
PSMB6 Antibody (B-6) Alexa Fluor® 594 | sc-515919 AF594 | 200 µg/ml | $357.00 | |||
PSMB6 Antibody (B-6) Alexa Fluor® 647 | sc-515919 AF647 | 200 µg/ml | $357.00 | |||
PSMB6 Antibody (B-6) Alexa Fluor® 680 | sc-515919 AF680 | 200 µg/ml | $357.00 | |||
PSMB6 Antibody (B-6) Alexa Fluor® 790 | sc-515919 AF790 | 200 µg/ml | $357.00 |