PSMB4 Antibody (H-3): sc-390878
- PSMB4 Antibody (H-3) is a mouse monoclonal IgG2a κ PSMB4 antibody, cited in 8 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 245-262 at the C-terminus of PSMB4 of human origin
- PSMB4 Antibody (H-3) is recommended for detection of PSMB4 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including bovine
- Anti-PSMB4 Antibody (H-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for PSMB4 Antibody (H-3) for WB and IHC(P) applications. This reagent is now offered in a bundle with PSMB4 Antibody (H-3) (see ordering information below).
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PSMB4 Antibody (H-3) is a mouse monoclonal IgG2a kappa light chain antibody that detects PSMB4 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). PSMB4 (H-3) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PSMB4 protein, also known as HN3, PROS26, or macropain β chain, is a critical β subunit of the 20S Proteasome, which plays a vital role in the selective degradation of cellular proteins. This process is essential for maintaining cellular homeostasis, regulating the cell cycle, and modulating various signaling pathways. The 20S Proteasome is composed of a cylindrical core made up of four stacked rings, with the outer two rings consisting of seven α subunits and the inner two rings containing seven β subunits, including PSMB4. Proper functioning of the proteasome ensures that damaged or misfolded proteins are efficiently removed from cells, preventing potential toxic accumulation and contributing to overall organism health. Anti-PSMB4 antibody (H-3) serves as a valuable tool for researchers studying proteasome function and its implications in various diseases, including cancer and neurodegenerative disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PSMB4 Antibody (H-3) References:
- Sequencing of amphioxus PSMB5/8 gene and phylogenetic position of agnathan sequences. | Takezaki, N., et al. 2002. Gene. 282: 179-87. PMID: 11814690
- The up-regulation of proteasome subunits and lysosomal proteases in hepatocellular carcinomas of the HBx gene knockin transgenic mice. | Cui, F., et al. 2006. Proteomics. 6: 498-504. PMID: 16317774
- Atrophy, hypertrophy, and hypoxemia induce transcriptional regulators of the ubiquitin proteasome system in the rat heart. | Razeghi, P., et al. 2006. Biochem Biophys Res Commun. 342: 361-4. PMID: 16483544
- Fibrolamellar carcinomas show overexpression of genes in the RAS, MAPK, PIK3, and xenobiotic degradation pathways. | Kannangai, R., et al. 2007. Hum Pathol. 38: 639-44. PMID: 17367606
- Intermediates in the formation of mouse 20S proteasomes: implications for the assembly of precursor beta subunits. | Nandi, D., et al. 1997. EMBO J. 16: 5363-75. PMID: 9311996
- Genetic relationships of the genes encoding the human proteasome beta subunits and the proteasome PA28 complex. | McCusker, D., et al. 1997. Genomics. 45: 362-7. PMID: 9344661
- Reactions of [14C]-3,4-dichloroisocoumarin with subunits of pituitary and spleen multicatalytic proteinase complexes (proteasomes). | Orlowski, M., et al. 1997. Biochemistry. 36: 13946-53. PMID: 9374874
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PSMB4 Antibody (H-3) | sc-390878 | 200 µg/ml | $316.00 | |||
PSMB4 Antibody (H-3): m-IgG Fc BP-HRP Bundle | sc-526203 | 200 µg Ab; 10 µg BP | $354.00 | |||
PSMB4 Antibody (H-3) AC | sc-390878 AC | 500 µg/ml, 25% agarose | $416.00 | |||
PSMB4 Antibody (H-3) HRP | sc-390878 HRP | 200 µg/ml | $316.00 | |||
PSMB4 Antibody (H-3) FITC | sc-390878 FITC | 200 µg/ml | $330.00 | |||
PSMB4 Antibody (H-3) PE | sc-390878 PE | 200 µg/ml | $343.00 | |||
PSMB4 Antibody (H-3) Alexa Fluor® 488 | sc-390878 AF488 | 200 µg/ml | $357.00 | |||
PSMB4 Antibody (H-3) Alexa Fluor® 546 | sc-390878 AF546 | 200 µg/ml | $357.00 | |||
PSMB4 Antibody (H-3) Alexa Fluor® 594 | sc-390878 AF594 | 200 µg/ml | $357.00 | |||
PSMB4 Antibody (H-3) Alexa Fluor® 647 | sc-390878 AF647 | 200 µg/ml | $357.00 | |||
PSMB4 Antibody (H-3) Alexa Fluor® 680 | sc-390878 AF680 | 200 µg/ml | $357.00 | |||
PSMB4 Antibody (H-3) Alexa Fluor® 790 | sc-390878 AF790 | 200 µg/ml | $357.00 | |||
PSMB4 (H-3) Neutralizing Peptide | sc-390878 P | 100 µg/0.5 ml | $68.00 |