PSD-93 Antibody (D-2): sc-515245
- PSD-93 Antibody (D-2) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- raised against amino acids 1-300 mapping at the N-terminus of PSD-93 of human origin
- recommended for detection of PSD-93, PSD-95, SAP97, SAP102 and PSD-95 related protein of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for PSD-93 Antibody (D-2) for WB applications. These reagents are now offered in bundles with PSD-93 Antibody (D-2) (see ordering information below).
PSD-93 Antibody (D-2) is a mouse monoclonal IgG2a antibody that detects PSD-93 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PSD-93, also known as channel-associated protein of synapse-110 or chapsyn-110, plays a crucial role in the assembly of signal transduction complexes at postsynaptic sites, particularly in hippocampal neurons. PSD-93 is essential for the clustering and anchoring of NMDA receptors at synapses, which is vital for synaptic plasticity and memory formation. Notably, PSD-93 interacts specifically with the glutamate receptor subunit δ2, which is predominantly found in Purkinje neuron cell bodies and dendrites. The co-localization of PSD-93 and δ2 at parallel fiber synapses underscores PSD-93′s importance in modulating synaptic transmission and ensuring proper neuronal communication. Anti-PSD-93 antibody (D-2) enables researchers to gain valuable insights into the dynamics of synaptic signaling and the underlying mechanisms of neurodevelopmental and neurodegenerative disorders.
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PSD-93 Antibody (D-2) References:
- Identification of PSD-93 as a substrate for the Src family tyrosine kinase Fyn. | Nada, S., et al. 2003. J Biol Chem. 278: 47610-21. PMID: 13129934
- Distribution of the scaffolding proteins PSD-95, PSD-93, and SAP97 in isolated PSDs. | DeGiorgis, JA., et al. 2006. Brain Cell Biol. 35: 239-50. PMID: 18392731
- Opposing effects of PSD-93 and PSD-95 on long-term potentiation and spike timing-dependent plasticity. | Carlisle, HJ., et al. 2008. J Physiol. 586: 5885-900. PMID: 18936077
- PSD-93 deletion inhibits Fyn-mediated phosphorylation of NR2B and protects against focal cerebral ischemia. | Zhang, M., et al. 2014. Neurobiol Dis. 68: 104-11. PMID: 24787897
- MAGUKs: multifaceted synaptic organizers. | Won, S., et al. 2017. Curr Opin Neurobiol. 43: 94-101. PMID: 28236779
- PSD-93 Attenuates Amyloid-β-Mediated Cognitive Dysfunction by Promoting the Catabolism of Amyloid-β. | Yu, L., et al. 2017. J Alzheimers Dis. 59: 913-927. PMID: 28697571
- PSD-93 Interacts with SynGAP and Promotes SynGAP Ubiquitination and Ischemic Brain Injury in Mice. | Zhang, Q., et al. 2020. Transl Stroke Res. 11: 1137-1147. PMID: 32130656
- PSD-93 mediates the crosstalk between neuron and microglia and facilitates acute ischemic stroke injury by binding to CX3CL1. | Zhang, Q., et al. 2021. J Neurochem. 157: 2145-2157. PMID: 33599284
- PSD-93 up-regulates the synaptic activity of corticotropin-releasing hormone neurons in the paraventricular nucleus in depression. | Qin, XY., et al. 2021. Acta Neuropathol. 142: 1045-1064. PMID: 34536123
- Rho-Kinase/ROCK Phosphorylates PSD-93 Downstream of NMDARs to Orchestrate Synaptic Plasticity. | Hossen, E., et al. 2022. Int J Mol Sci. 24: PMID: 36613848
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PSD-93 Antibody (D-2) | sc-515245 | 200 µg/ml | $322.00 | |||
PSD-93 Antibody (D-2): m-IgG Fc BP-HRP Bundle | sc-541039 | 200 µg Ab; 10 µg BP | $361.00 | |||
PSD-93 Antibody (D-2): m-IgG2a BP-HRP Bundle | sc-547005 | 200 µg Ab; 10 µg BP | $361.00 |