Prostate Specific Antigen/AACT Complex Antibody (4G10): sc-53144

PSA/ACT Antibody (4G10) is a mouse monoclonal IgG1 kappa light chain antibody that detects the PSA/ACT protein of human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-PSA/ACT antibody (4G10) is available as the non-conjugated format. Prostate specific antigen (PSA), also known as gamma-seminoprotein, seminin, p30 antigen, semenogelase, and kallikrein 3 (KLK3), is a serine protease primarily produced in the prostate gland, where PSA plays a crucial role in the liquefaction of semen by hydrolyzing semenogelin I, a major protein in seminal fluid. This enzymatic activity is essential for fertility, as PSA allows sperm to swim freely after ejaculation. Elevated levels of PSA in the blood are often associated with prostate cancer, making PSA a vital biomarker for early detection and monitoring of the disease. Additionally, PSA has been found in other tissues, including accessory male sex glands and breast cancer, highlighting PSA′s potential relevance beyond prostate pathology. PSA/ACT (4G10) monoclonal antibody′s specific targeting ability makes PSA/ACT (4G10) antibody an invaluable tool for researchers studying prostate cancer and its associated mechanisms.

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Prostate Specific Antigen/AACT Complex Antibody (4G10) References:

1. Analysis of free prostate-specific antigen (PSA) after chemical release from the complex with alpha(1)-antichymotrypsin (PSA-ACT).  |  Peter, J., et al. 2000. Clin Chem. 46: 474-82. PMID: 10759471
2. Human prostate-specific antigen: structural and functional similarity with serine proteases.  |  Watt, KW., et al. 1986. Proc Natl Acad Sci U S A. 83: 3166-70. PMID: 2422647
3. Molecular cloning of human prostate specific antigen cDNA.  |  Lundwall, A. and Lilja, H. 1987. FEBS Lett. 214: 317-22. PMID: 2436946
4. Isolation, characterization and amino-acid sequence of gamma-seminoprotein, a glycoprotein from human seminal plasma.  |  Schaller, J., et al. 1987. Eur J Biochem. 170: 111-20. PMID: 3691515
5. Detection of organ-confined prostate cancer is increased through prostate-specific antigen-based screening.  |  Catalona, WJ., et al. 1993. JAMA. 270: 948-54. PMID: 7688438
6. Biochemical characteristics and recent biological knowledge on prostate-specific antigen.  |  Seregni, E., et al. 1996. Tumori. 82: 72-7. PMID: 8623511
7. Purification and characterization of the active precursor of a human sperm motility inhibitor secreted by the seminal vesicles: identity with semenogelin.  |  Robert, M. and Gagnon, C. 1996. Biol Reprod. 55: 813-21. PMID: 8879494
8. Antigenic determinants of prostate-specific antigen (PSA) and development of assays specific for different forms of PSA.  |  Nilsson, O., et al. 1997. Br J Cancer. 75: 789-97. PMID: 9062397
9. Enhancing the specificity of prostate-specific antigen (PSA): an overview of PSA density, velocity and age-specific reference ranges.  |  Nixon, RG. and Brawer, MK. 1997. Br J Urol. 79 Suppl 1: 61-7. PMID: 9088275
10. Characterization of prostate-specific antigen proteolytic activity on its major physiological substrate, the sperm motility inhibitor precursor/semenogelin I.  |  Robert, M., et al. 1997. Biochemistry. 36: 3811-9. PMID: 9092810
11. Prostate-specific antigen and early detection of prostate cancer.  |  Chu, TM. 1997. Tumour Biol. 18: 123-34. PMID: 9222310
12. Monoclonal antibodies 2F5 and 4G10 against prostate specific antigen (PSA) complexed to alpha1-antichymotrypsin.  |  Chen, Z., et al. 1998. J Urol. 160: 870-5. PMID: 9720579

The preferred PSA/KLK3/Kallikrein 3/Prostate Specific Antigen antibody is PSA/KLK3/Kallikrein 3/Prostate Specific Antigen Antibody (A67-B/E3): sc-7316.