PRX1 Antibody (1E2): sc-293386

PRX1 Antibody (1E2) is a mouse monoclonal IgG1 kappa light chain antibody that detects PRX1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-PRX1 antibody (1E2) is available as the non-conjugated format. PRX1, also known as paired related homeobox 1, plays a crucial role in gene expression regulation, particularly in muscle development and differentiation. PRX1 contains a homeobox DNA-binding domain, essential for function as a transcriptional co-activator. This domain allows PRX1 to bind to specific DNA sequences, enhancing serum response factor (SRF) activity, a key regulator of genes involved in muscle cell growth and differentiation. PRX1′s interaction with SRF is vital for inducing SRF-dependent gene expression, critical during mesodermal muscle type establishment. PRX1 exists in two alternatively spliced isoforms, PMX1-A and PMX1-B, which may have distinct regulatory roles in various biological processes. Anti-PRX1 antibody (1E2) enables researchers to explore PRX1′s intricate functions in developmental biology and muscle physiology, providing insights into potential implications in muscle-related diseases and regenerative medicine.

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PRX1 Antibody (1E2) References:

1. NUP98 is fused to PMX1 homeobox gene in human acute myelogenous leukemia with chromosome translocation t(1;11)(q23;p15).  |  Nakamura, T., et al. 1999. Blood. 94: 741-7. PMID: 10397741
2. Human PRRX1 and PRRX2 genes: cloning, expression, genomic localization, and exclusion as disease genes for Nager syndrome.  |  Norris, RA., et al. 2000. Mamm Genome. 11: 1000-5. PMID: 11063257
3. Prx1 controls vascular smooth muscle cell proliferation and tenascin-C expression and is upregulated with Prx2 in pulmonary vascular disease.  |  Jones, FS., et al. 2001. Circ Res. 89: 131-8. PMID: 11463719
4. Human and Drosophila homeodomain proteins that enhance the DNA-binding activity of serum response factor.  |  Grueneberg, DA., et al. 1992. Science. 257: 1089-95. PMID: 1509260
5. Human prx1 gene is a target of Nrf2 and is up-regulated by hypoxia/reoxygenation: implication to tumor biology.  |  Kim, YJ., et al. 2007. Cancer Res. 67: 546-54. PMID: 17234762
6. Homeobox gene Prx1 is expressed in activated hepatic stellate cells and transactivates collagen alpha1(I) promoter.  |  Jiang, F. and Stefanovic, B. 2008. Exp Biol Med (Maywood). 233: 286-96. PMID: 18296734
7. Leukemogenic properties of NUP98-PMX1 are linked to NUP98 and homeodomain sequence functions but not to binding properties of PMX1 to serum response factor.  |  Hirose, K., et al. 2008. Oncogene. 27: 6056-67. PMID: 18604245

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PRX1 Antibody (1E2) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-PRX1 Antibody (1E2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PRX1 Antibody (1E2) Specifications

Alternate Product Name: PRX1

Product Clone Name: 1E2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-90

Epitope Target: PRX1

Epitope Species: human

Product Reactivity/Detection: PRX1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for PRX1 Antibody (1E2): N/A