PRX IV Antibody (F-2): sc-376668
- PRX IV Antibody (F-2) is a mouse monoclonal IgG1 κ PRX IV antibody, cited in 5 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 121-155 within an internal region of PRX IV of human origin
- PRX IV Antibody (F-2) is recommended for detection of PRX IV of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-PRX IV Antibody (F-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgGκ BP-HRP is the preferred secondary detection reagent for PRX IV Antibody (F-2) for WB applications. This reagent is now offered in a bundle with PRX IV Antibody (F-2) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
PRX IV Antibody (F-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects PRX IV protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-PRX IV antibody (F-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PRX IV protein, also known as Peroxiredoxin-4, plays a crucial role in cellular defense against oxidative stress by reducing reactive oxygen species (ROS), thereby protecting cells from damage that can lead to various diseases, including cancer and neurodegenerative disorders. PRX IV is primarily localized in the endoplasmic reticulum and is secreted into the extracellular space, where PRX IV can exert protective effects on surrounding cells. Such unique localization of PRX IV is significant because PRX IV allows for ROS detoxification in a compartment where protein folding and maturation occur, thus maintaining cellular homeostasis. PRX IV is involved in various cellular processes, including cell proliferation and differentiation, highlighting PRX IV′s importance in both normal physiology and disease states. Human PRX IV gene is abundantly expressed across many tissues, indicating PRX IV′s essential role in maintaining cellular health and function.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PRX IV Antibody (F-2) References:
- Peroxiredoxin I (macrophage 23 kDa stress protein) is highly and widely expressed in the rat nervous system. | Mizusawa, H., et al. 2000. Neurosci Lett. 283: 57-60. PMID: 10729633
- From cytoprotection to tumor suppression: the multifactorial role of peroxiredoxins. | Butterfield, LH., et al. 1999. Antioxid Redox Signal. 1: 385-402. PMID: 11233141
- Overexpression of peroxiredoxin in human breast cancer. | Noh, DY., et al. 2001. Anticancer Res. 21: 2085-90. PMID: 11497302
- Protein levels of human peroxiredoxin subtypes in brains of patients with Alzheimer's disease and Down syndrome. | Kim, SH., et al. 2001. J Neural Transm Suppl. 223-35. PMID: 11771746
- Cell specific expression of peroxiredoxins in human lung and pulmonary sarcoidosis. | Kinnula, VL., et al. 2002. Thorax. 57: 157-64. PMID: 11828047
- Peroxiredoxins. | Hofmann, B., et al. 2002. Biol Chem. 383: 347-64. PMID: 12033427
- Advances in our understanding of peroxiredoxin, a multifunctional, mammalian redox protein. | Fujii, J. and Ikeda, Y. 2002. Redox Rep. 7: 123-30. PMID: 12189041
- Mice with targeted mutation of peroxiredoxin 6 develop normally but are susceptible to oxidative stress. | Wang, X., et al. 2003. J Biol Chem. 278: 25179-90. PMID: 12732627
- Purification, characterization, and cloning of a heme-binding protein (23 kDa) in rat liver cytosol. | Iwahara, S., et al. 1995. Biochemistry. 34: 13398-406. PMID: 7577926
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PRX IV Antibody (F-2) | sc-376668 | 200 µg/ml | $322.00 | |||
PRX IV Antibody (F-2): m-IgGκ BP-HRP Bundle | sc-551103 | 200 µg Ab; 40 µg BP | $361.00 | |||
PRX IV Antibody (F-2) AC | sc-376668 AC | 500 µg/ml, 25% agarose | $424.00 | |||
PRX IV Antibody (F-2) HRP | sc-376668 HRP | 200 µg/ml | $322.00 | |||
PRX IV Antibody (F-2) FITC | sc-376668 FITC | 200 µg/ml | $336.00 | |||
PRX IV Antibody (F-2) PE | sc-376668 PE | 200 µg/ml | $349.00 | |||
PRX IV Antibody (F-2) Alexa Fluor® 488 | sc-376668 AF488 | 200 µg/ml | $364.00 | |||
PRX IV Antibody (F-2) Alexa Fluor® 546 | sc-376668 AF546 | 200 µg/ml | $364.00 | |||
PRX IV Antibody (F-2) Alexa Fluor® 594 | sc-376668 AF594 | 200 µg/ml | $364.00 | |||
PRX IV Antibody (F-2) Alexa Fluor® 647 | sc-376668 AF647 | 200 µg/ml | $364.00 | |||
PRX IV Antibody (F-2) Alexa Fluor® 680 | sc-376668 AF680 | 200 µg/ml | $364.00 | |||
PRX IV Antibody (F-2) Alexa Fluor® 790 | sc-376668 AF790 | 200 µg/ml | $364.00 | |||
PRX IV (F-2) Neutralizing Peptide | sc-376668 P | 100 µg/0.5 ml | $69.00 |