PRX II Antibody (A-2): sc-515428
- PRX II Antibody (A-2) is a mouse monoclonal IgG2a κ PRX II antibody, cited in 9 publications, provided at 200 µg/ml
- raised against amino acids 1-40 mapping at the N-terminus of PRX II of mouse origin
- PRX II Antibody (A-2) is recommended for detection of PRX II of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-PRX II Antibody (A-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for PRX II Antibody (A-2) for WB applications. These reagents are now offered in bundles with PRX II Antibody (A-2) (see ordering information below).
PRX II Antibody (A-2) is a mouse monoclonal IgG2a kappa light chain antibody that detects PRX II protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-PRX II antibody (A-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PRX II protein, part of the peroxiredoxin family, plays a crucial role in cellular defense against oxidative stress by reducing reactive oxygen species (ROS), thereby protecting cells from damage that can lead to various diseases, including cancer and neurodegenerative disorders. PRX II is predominantly localized in the cytoplasm, where PRX II interacts with thioredoxin to facilitate antioxidant functions. This localization enables effective neutralization of ROS generated during cellular metabolism, maintaining cellular homeostasis and preventing oxidative damage. Expression levels of PRX II are notably increased in certain cancers, such as breast cancer, and in conditions like Alzheimer′s disease, highlighting PRX II′s potential role in disease progression and pathogenesis. Using PRX II (A-2) antibody in research can provide valuable insights into oxidative stress mechanisms and their implications in various biological processes and diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PRX II Antibody (A-2) References:
- Peroxiredoxin I (macrophage 23 kDa stress protein) is highly and widely expressed in the rat nervous system. | Mizusawa, H., et al. 2000. Neurosci Lett. 283: 57-60. PMID: 10729633
- From cytoprotection to tumor suppression: the multifactorial role of peroxiredoxins. | Butterfield, LH., et al. 1999. Antioxid Redox Signal. 1: 385-402. PMID: 11233141
- Overexpression of peroxiredoxin in human breast cancer. | Noh, DY., et al. 2001. Anticancer Res. 21: 2085-90. PMID: 11497302
- Protein levels of human peroxiredoxin subtypes in brains of patients with Alzheimer's disease and Down syndrome. | Kim, SH., et al. 2001. J Neural Transm Suppl. 223-35. PMID: 11771746
- Cell specific expression of peroxiredoxins in human lung and pulmonary sarcoidosis. | Kinnula, VL., et al. 2002. Thorax. 57: 157-64. PMID: 11828047
- Peroxiredoxins. | Hofmann, B., et al. 2002. Biol Chem. 383: 347-64. PMID: 12033427
- Advances in our understanding of peroxiredoxin, a multifunctional, mammalian redox protein. | Fujii, J. and Ikeda, Y. 2002. Redox Rep. 7: 123-30. PMID: 12189041
- Mice with targeted mutation of peroxiredoxin 6 develop normally but are susceptible to oxidative stress. | Wang, X., et al. 2003. J Biol Chem. 278: 25179-90. PMID: 12732627
- Purification, characterization, and cloning of a heme-binding protein (23 kDa) in rat liver cytosol. | Iwahara, S., et al. 1995. Biochemistry. 34: 13398-406. PMID: 7577926
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PRX II Antibody (A-2) | sc-515428 | 200 µg/ml | $322.00 | |||
PRX II Antibody (A-2): m-IgG Fc BP-HRP Bundle | sc-531362 | 200 µg Ab; 10 µg BP | $361.00 | |||
PRX II Antibody (A-2): m-IgGκ BP-HRP Bundle | sc-525034 | 200 µg Ab, 40 µg BP | $361.00 | |||
PRX II Antibody (A-2): m-IgG2a BP-HRP Bundle | sc-547772 | 200 µg Ab; 10 µg BP | $361.00 | |||
PRX II Antibody (A-2) AC | sc-515428 AC | 500 µg/ml, 25% agarose | $424.00 | |||
PRX II Antibody (A-2) HRP | sc-515428 HRP | 200 µg/ml | $322.00 | |||
PRX II Antibody (A-2) FITC | sc-515428 FITC | 200 µg/ml | $336.00 | |||
PRX II Antibody (A-2) PE | sc-515428 PE | 200 µg/ml | $349.00 | |||
PRX II Antibody (A-2) Alexa Fluor® 488 | sc-515428 AF488 | 200 µg/ml | $364.00 | |||
PRX II Antibody (A-2) Alexa Fluor® 546 | sc-515428 AF546 | 200 µg/ml | $364.00 | |||
PRX II Antibody (A-2) Alexa Fluor® 594 | sc-515428 AF594 | 200 µg/ml | $364.00 | |||
PRX II Antibody (A-2) Alexa Fluor® 647 | sc-515428 AF647 | 200 µg/ml | $364.00 | |||
PRX II Antibody (A-2) Alexa Fluor® 680 | sc-515428 AF680 | 200 µg/ml | $364.00 | |||
PRX II Antibody (A-2) Alexa Fluor® 790 | sc-515428 AF790 | 200 µg/ml | $364.00 |