PRR18 Antibody (G-6): sc-398597

PRR18 Antibody (G-6) is a mouse monoclonal IgM antibody that detects PRR18 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-PRR18 antibody (G-6) is available as the non-conjugated form. PRR18, consisting of 295 amino acids, plays a crucial role in cellular signaling and protein-protein interactions, particularly as a ligand for SH3, WW, and EVH1 domains, which are essential for various cellular processes including cytoskeletal organization and signal transduction. Understanding PRR18 function is vital, as PRR18 may influence pathways related to cell growth and differentiation, and PRR18 dysregulation has been implicated in several diseases, including cancer. PRR18 gene is located on human chromosome 6q27, a region associated with various genetic disorders and cancer susceptibility, highlighting PRR18′s importance in both normal physiology and disease states. Using PRR18 (G-6) antibody in research can provide insights into PRR18′s functional dynamics and potential implications in health and disease.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

PRR18 Antibody (G-6) References:

1. The importance of being proline: the interaction of proline-rich motifs in signaling proteins with their cognate domains.  |  Kay, BK., et al. 2000. FASEB J. 14: 231-41. PMID: 10657980
2. Parkin, a gene implicated in autosomal recessive juvenile parkinsonism, is a candidate tumor suppressor gene on chromosome 6q25-q27.  |  Cesari, R., et al. 2003. Proc Natl Acad Sci U S A. 100: 5956-61. PMID: 12719539
3. Recurrent deletions at 6q in early age of onset non-HNPCC- and non-FAP-associated intestinal carcinomas. Evidence for a novel cancer susceptibility locus at 6q14-q22.  |  Bläker, H., et al. 2008. Genes Chromosomes Cancer. 47: 159-64. PMID: 18008368
4. Regional assignment of two genes of the human branched-chain alpha-keto acid dehydrogenase complex: the E1 beta gene (BCKDHB) to chromosome 6p21-22 and the E2 gene (DBT) to chromosome 1p31.  |  Zneimer, SM., et al. 1991. Genomics. 10: 740-7. PMID: 1889817
5. Linkage disequilibrium mapping of the chromosome 6q21-22.31 bipolar I disorder susceptibility locus.  |  Fan, J., et al. 2010. Am J Med Genet B Neuropsychiatr Genet. 153B: 29-37. PMID: 19308960
6. Associations among behavior-related susceptibility factors in porphyria cutanea tarda.  |  Jalil, S., et al. 2010. Clin Gastroenterol Hepatol. 8: 297-302, 302.e1. PMID: 19948245
7. A Stickler syndrome gene is linked to chromosome 6 near the COL11A2 gene.  |  Brunner, HG., et al. 1994. Hum Mol Genet. 3: 1561-4. PMID: 7833911
8. FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands.  |  Bedford, MT., et al. 1997. EMBO J. 16: 2376-83. PMID: 9171351

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PRR18 Antibody (G-6) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-PRR18 Antibody (G-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PRR18 Antibody (G-6) Specifications

Alternate Product Name: PRR18

Product Clone Name: G-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 222-254

Epitope Target: PRR18

Epitope Species: human

Product Reactivity/Detection: PRR18

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for PRR18 Antibody (G-6): P: Blocking Peptide