PRPSAP2 Antibody (A-1): sc-376025

PRPSAP2 Antibody (A-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects PRPSAP2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PRPSAP2 Antibody (A-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PRPSAP2, also known as phosphoribosyl pyrophosphate synthetase-associated protein 2, is a 369 amino acid protein that plays a crucial role in the regulation of nucleotide synthesis by interacting with the catalytic subunits of phosphoribosylpyrophosphate synthetase, PRPS1 and PRPS2. This interaction is vital for the formation of phosphoribosylpyrophosphate, an essential substrate for the synthesis of purine and pyrimidine nucleotides, as well as amino acids like histidine and tryptophan. Proper functioning of PRPSAP2 is important for maintaining cellular metabolism and energy balance, as disruptions in nucleotide synthesis can lead to various metabolic disorders. PRPSAP2 is ubiquitously expressed, indicating its fundamental role in cellular processes across different tissues.

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PRPSAP2 Antibody (A-1) References:

1. [Increased activity of PRPP synthetase].  |  Iizasa, T. 2008. Nihon Rinsho. 66: 694-8. PMID: 18409517
2. PRPS1 mutations: four distinct syndromes and potential treatment.  |  de Brouwer, AP., et al. 2010. Am J Hum Genet. 86: 506-18. PMID: 20380929
3. Hyperuricemia cosegregating with osteogenesis imperfecta is associated with a mutation in GPATCH8.  |  Kaneko, H., et al. 2011. Hum Genet. 130: 671-83. PMID: 21594610
4. Identification of novel candidate oncogenes in chromosome region 17p11.2-p12 in human osteosarcoma.  |  Both, J., et al. 2012. PLoS One. 7: e30907. PMID: 22292074
5. Oncogenic Properties of Candidate Oncogenes in Chromosome Region 17p11.2p12 in Human Osteosarcoma.  |  Both, J., et al. 2016. Cytogenet Genome Res. 150: 52-59. PMID: 27846620
6. Evaluating the Neuroimaging-Genetic Prediction of Symptom Changes in Individuals with ADHD.  |  Suresh, P., et al. 2021. Annu Int Conf IEEE Eng Med Biol Soc. 2021: 1950-1956. PMID: 34891669
7. [Range of the transmissivity of the genetic transfer factors pAP38, pAP39, pAP41 and pAP42].  |  Avdienko, ID., et al. 1983. Biull Eksp Biol Med. 95: 76-7. PMID: 6299434
8. [Mammalian phosphoribosylpyrophosphate synthetase].  |  Tatibana, M. 1996. Nihon Rinsho. 54: 3195-201. PMID: 8976091
9. [PRPP synthetase superactivity].  |  Fujimori, S. 1996. Nihon Rinsho. 54: 3309-14. PMID: 8976111
10. Cloning and sequencing of rat cDNA for the 41-kDa phosphoribosylpyrophosphate synthetase-associated protein has a high homology to the catalytic subunits and the 39-kDa associated protein.  |  Sonoda, T., et al. 1997. Biochim Biophys Acta. 1350: 6-10. PMID: 9003449
11. Molecular cloning of a human cDNA for the 41-kDa phosphoribosylpyrophosphate synthetase-associated protein.  |  Katashima, R., et al. 1998. Biochim Biophys Acta. 1396: 245-50. PMID: 9545573
12. Assignment of the human phosphoribosylpyrophosphate synthetase-associated protein 41 gene (PRPSAP2) to 17p11.2-p12.  |  Katashima, R., et al. 1998. Genomics. 54: 180-1. PMID: 9806849

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PRPSAP2 Antibody (A-1) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-PRPSAP2 Antibody (A-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PRPSAP2 Antibody (A-1) Specifications

Alternate Product Name: PRPSAP2

Product Clone Name: A-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-23

Epitope Target: PRPSAP2

Epitope Species: human

Product Reactivity/Detection: PRPSAP2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for PRPSAP2 Antibody (A-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin