PRPSAP1 Antibody (A-9): sc-398422
- PRPSAP1 Antibody (A-9) is a mouse monoclonal IgG1 κ PRPSAP1 antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 29-120 mapping near the N-terminus of PRPSAP1 of human origin
- PRPSAP1 Antibody (A-9) is recommended for detection of PRPSAP1 of mouse, rat, human and origin by WB, IP, IF and ELISA; also reactive with additional species, including and canine, bovine, porcine and avian
- Anti-PRPSAP1 Antibody (A-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for PRPSAP1 Antibody (A-9) for WB applications. These reagents are now offered in bundles with PRPSAP1 Antibody (A-9) (see ordering information below).
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PRPSAP1 Antibody (A-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects PRPSAP1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PRPSAP1 (A-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PRPSAP1, also known as phosphoribosyl pyrophosphate synthetase-associated protein 1 or PAP39, is a 356 amino acid protein that plays a crucial role in nucleotide metabolism by modulating phosphoribosylpyrophosphate synthetase (PRS) activity, which is essential for purine and pyrimidine nucleotides synthesis, as well as histidine, tryptophan, and NAD production. Located in the cytoplasm, PRPSAP1 interacts with catalytic subunits PRPS1 and PRPS2, forming a complex that regulates phosphoribosylpyrophosphate production, a key substrate in nucleotide biosynthesis. PRPSAP1 regulation is vital, as PRPSAP1 can influence cellular proliferation and metabolism, making PRPSAP1 an important target for studies related to cancer and metabolic disorders. The gene encoding PRPSAP1 is located on human chromosome 17q25.1, highlighting PRPSAP1′s evolutionary conservation and significance across species.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PRPSAP1 Antibody (A-9) References:
- [Increased activity of PRPP synthetase]. | Iizasa, T. 2008. Nihon Rinsho. 66: 694-8. PMID: 18409517
- PRPS1 mutations: four distinct syndromes and potential treatment. | de Brouwer, AP., et al. 2010. Am J Hum Genet. 86: 506-18. PMID: 20380929
- [Range of the transmissivity of the genetic transfer factors pAP38, pAP39, pAP41 and pAP42]. | Avdienko, ID., et al. 1983. Biull Eksp Biol Med. 95: 76-7. PMID: 6299434
- [Mammalian phosphoribosylpyrophosphate synthetase]. | Tatibana, M. 1996. Nihon Rinsho. 54: 3195-201. PMID: 8976091
- [PRPP synthetase superactivity]. | Fujimori, S. 1996. Nihon Rinsho. 54: 3309-14. PMID: 8976111
- Cloning and sequencing of rat cDNA for the 41-kDa phosphoribosylpyrophosphate synthetase-associated protein has a high homology to the catalytic subunits and the 39-kDa associated protein. | Sonoda, T., et al. 1997. Biochim Biophys Acta. 1350: 6-10. PMID: 9003449
- Molecular cloning of a human cDNA for the 41-kDa phosphoribosylpyrophosphate synthetase-associated protein. | Katashima, R., et al. 1998. Biochim Biophys Acta. 1396: 245-50. PMID: 9545573
- Assignment of the human phosphoribosylpyrophosphate synthetase-associated protein 41 gene (PRPSAP2) to 17p11.2-p12. | Katashima, R., et al. 1998. Genomics. 54: 180-1. PMID: 9806849
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PRPSAP1 Antibody (A-9) | sc-398422 | 200 µg/ml | $322.00 | |||
PRPSAP1 Antibody (A-9): m-IgG Fc BP-HRP Bundle | sc-530789 | 200 µg Ab; 10 µg BP | $361.00 | |||
PRPSAP1 Antibody (A-9): m-IgGκ BP-HRP Bundle | sc-524332 | 200 µg Ab, 40 µg BP | $361.00 | |||
PRPSAP1 Antibody (A-9): m-IgG1 BP-HRP Bundle | sc-544253 | 200 µg Ab; 20 µg BP | $361.00 | |||
PRPSAP1 Antibody (A-9) AC | sc-398422 AC | 500 µg/ml, 25% agarose | $424.00 | |||
PRPSAP1 Antibody (A-9) HRP | sc-398422 HRP | 200 µg/ml | $322.00 | |||
PRPSAP1 Antibody (A-9) FITC | sc-398422 FITC | 200 µg/ml | $336.00 | |||
PRPSAP1 Antibody (A-9) PE | sc-398422 PE | 200 µg/ml | $349.00 | |||
PRPSAP1 Antibody (A-9) Alexa Fluor® 488 | sc-398422 AF488 | 200 µg/ml | $364.00 | |||
PRPSAP1 Antibody (A-9) Alexa Fluor® 546 | sc-398422 AF546 | 200 µg/ml | $364.00 | |||
PRPSAP1 Antibody (A-9) Alexa Fluor® 594 | sc-398422 AF594 | 200 µg/ml | $364.00 | |||
PRPSAP1 Antibody (A-9) Alexa Fluor® 647 | sc-398422 AF647 | 200 µg/ml | $364.00 | |||
PRPSAP1 Antibody (A-9) Alexa Fluor® 680 | sc-398422 AF680 | 200 µg/ml | $364.00 | |||
PRPSAP1 Antibody (A-9) Alexa Fluor® 790 | sc-398422 AF790 | 200 µg/ml | $364.00 |