PRPF38A Antibody (F-7): sc-373907

PRPF38A Antibody (F-7) is a mouse monoclonal IgG3 kappa light chain antibody that detects PRPF38A protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-PRPF38A antibody (F-7) is available as the non-conjugated form. PRPF38A, also known as Pre-mRNA-splicing factor 38A, is a crucial 312 amino acid nuclear protein that plays a significant role in pre-mRNA splicing, essential for messenger RNA maturation and gene expression regulation. PRPF38A (F-7) antibody targets a protein located in the nucleus, where PRPF38A participates in spliceosome assembly and function, ensuring accurate removal of introns from pre-mRNA transcripts. Proper functioning of PRPF38A is vital, as splicing errors can lead to various diseases, including cancer and neurodegenerative disorders. PRPF38A is encoded by a gene on human chromosome 1, notable for associations with numerous genetic disorders, including Hutchinson-Gilford progeria and familial adenomatous polyposis. Two isoforms of PRPF38A, resulting from alternative splicing, highlight this protein′s complexity and regulatory potential in cellular processes.

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PRPF38A Antibody (F-7) References:

1. Report and abstracts of the sixth international workshop on human chromosome 1 mapping 2000. Iowa City, Iowa, USA. 30 September-3 October 2000.  |  Schutte, BC., et al. 2001. Cytogenet Cell Genet. 92: 23-41. PMID: 11306795
2. The origin of human chromosome 1 and its homologs in placental mammals.  |  Murphy, WJ., et al. 2003. Genome Res. 13: 1880-8. PMID: 12869576
3. [Splicing site mutation of D19S418 in PRPF-31 gene and its phenotypic characters with autosomal dominant retinitis pigmentosa].  |  Xi, XH., et al. 2005. Zhonghua Yan Ke Za Zhi. 41: 1020-6. PMID: 16318756
4. The DNA sequence and biological annotation of human chromosome 1.  |  Gregory, SG., et al. 2006. Nature. 441: 315-21. PMID: 16710414
5. Structure and function of regulatory RNA elements: ribozymes that regulate gene expression.  |  Scott, WG., et al. 2009. Biochim Biophys Acta. 1789: 634-41. PMID: 19781673
6. Spliceosomes walk the line: splicing errors and their impact on cellular function.  |  Hsu, SN. and Hertel, KJ. 2009. RNA Biol. 6: 526-30. PMID: 19829058
7. RNA modifications: a mechanism that modulates gene expression.  |  Karijolich, J., et al. 2010. Methods Mol Biol. 629: 1-19. PMID: 20387139
8. Quantitative analysis of RNA modifications.  |  Karijolich, J., et al. 2010. Methods Mol Biol. 629: 21-32. PMID: 20387140

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PRPF38A Antibody (F-7) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-PRPF38A Antibody (F-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PRPF38A Antibody (F-7) Specifications

Alternate Product Name: PRPF38A

Product Clone Name: F-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 157-180

Epitope Target: PRPF38A

Epitope Species: human

Product Reactivity/Detection: PRPF38A

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, porcine and avian

Additional Non-Mammalian Reactivity: avian

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for PRPF38A Antibody (F-7): P: Blocking Peptide