PRPF3 Antibody (B-1): sc-518271

PRPF3 Antibody (B-1) is a monoclonal antibody that detects PRPF3 in human samples through applications such as western blotting (WB), immunofluorescence (IF), and immunoprecipitation (IP). PRPF3, or Pre-mRNA Processing Factor 3, plays a crucial role in the splicing of pre-mRNA, a fundamental process that ensures proper gene expression. PRPF3 is primarily located in the nucleus, where PRPF3 is involved in the assembly of the spliceosome, the complex responsible for removing introns from pre-mRNA transcripts. The efficient splicing of pre-mRNA is vital for generating mature mRNA, which ultimately translates into functional proteins necessary for various cellular processes. Dysregulation of PRPF3 and splicing activity can lead to a range of diseases, including certain types of cancer and neurodegenerative disorders, highlighting PRPF3′s importance in maintaining cellular health. Anti-PRPF3 antibody (B-1) is an essential tool for researchers studying gene expression and splicing mechanisms, providing valuable insights into the molecular underpinnings of various diseases.

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PRPF3 Antibody (B-1) References:

1. Mutations in the pre-mRNA splicing-factor genes PRPF3, PRPF8, and PRPF31 in Spanish families with autosomal dominant retinitis pigmentosa.  |  Martínez-Gimeno, M., et al. 2003. Invest Ophthalmol Vis Sci. 44: 2171-7. PMID: 12714658
2. Mutations in splicing factor PRPF3, causing retinal degeneration, form detrimental aggregates in photoreceptor cells.  |  Comitato, A., et al. 2007. Hum Mol Genet. 16: 1699-707. PMID: 17517693
3. EPS15R, TASP1, and PRPF3 are novel disease candidate genes targeted by HNF4alpha splice variants in hepatocellular carcinomas.  |  Niehof, M. and Borlak, J. 2008. Gastroenterology. 134: 1191-202. PMID: 18395097
4. Variable phenotypic expressivity in a Swiss family with autosomal dominant retinitis pigmentosa due to a T494M mutation in the PRPF3 gene.  |  Vaclavik, V., et al. 2010. Mol Vis. 16: 467-75. PMID: 20309403
5. Temporal and tissue specific regulation of RP-associated splicing factor genes PRPF3, PRPF31 and PRPC8--implications in the pathogenesis of RP.  |  Cao, H., et al. 2011. PLoS One. 6: e15860. PMID: 21283520
6. Two novel mutations in PRPF3 causing autosomal dominant retinitis pigmentosa.  |  Zhong, Z., et al. 2016. Sci Rep. 6: 37840. PMID: 27886254
7. Corrigendum: Two novel mutations in PRPF3 causing autosomal dominant retinitis pigmentosa.  |  Zhong, Z., et al. 2017. Sci Rep. 7: 45248. PMID: 28350375
8. PRPF3-Associated Autosomal Dominant Retinitis Pigmentosa and CYP4V2-Associated Bietti's Crystalline Corneoretinal Dystrophy Coexist in a Multigenerational Chinese Family.  |  Meng, X., et al. 2017. J Ophthalmol. 2017: 4156386. PMID: 28848678
9. Prognostic potential of PRPF3 in hepatocellular carcinoma.  |  Liu, Y., et al. 2020. Aging (Albany NY). 12: 912-930. PMID: 31926109
10. Pre-mRNA processing factor 3 enhances the progression of keratinocyte-derived cutaneous squamous cell carcinoma by regulating the JAK2/STAT3 pathway.  |  Zuo, S., et al. 2020. Sci Rep. 10: 8863. PMID: 32483193
11. TMEM43 promotes pancreatic cancer progression by stabilizing PRPF3 and regulating RAP2B/ERK axis.  |  Li, J., et al. 2022. Cell Mol Biol Lett. 27: 24. PMID: 35260078
12. Integrative analysis based on ATAC-seq and RNA-seq reveals a novel oncogene PRPF3 in hepatocellular carcinoma.  |  Bai, Y., et al. 2024. Clin Epigenetics. 16: 154. PMID: 39501301

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PRPF3 Antibody (B-1) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-PRPF3 Antibody (B-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PRPF3 Antibody (B-1) Specifications

Alternate Product Name: PRPF3

Product Clone Name: B-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 648-674

Epitope Target: PRPF3

Epitope Species: human

Product Reactivity/Detection: PRPF3

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for PRPF3 Antibody (B-1): N/A