Protein S Antibody (C-5): sc-271400
- Protein S Antibody (C-5) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- raised against amino acids 81-170 of Protein S of human origin
- recommended for detection of Protein S of human origin by WB, IP, IF and ELISA
- m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Protein S Antibody (C-5) for WB applications. These reagents are now offered in bundles with Protein S Antibody (C-5) (see ordering information below).
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Protein S Antibody (C-5) is a mouse monoclonal IgG2a antibody that detects Protein S in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Protein S is a crucial vitamin K-dependent plasma protein that plays a significant role in the regulation of blood coagulation and the clearance of apoptotic cells. Anti-Protein S antibody (C-5) functions primarily as a cofactor for activated protein C (APC), enhancing the anticoagulant pathway and preventing excessive clot formation. Notably, Protein S exists in a complex with C4b-binding protein (C4BP) in the plasma, which renders a significant portion inactive; approximately 60-70% of circulating Protein S is bound to C4BP. This calcium-dependent interaction not only influences the regulation of complement activation but also highlights the importance of Protein S in maintaining hemostatic balance. Furthermore, Protein S exhibits APC-independent anticoagulant activity by directly inhibiting prothrombin activation through interactions with Factor Xa, Factor Va, and phospholipids, underscoring its multifaceted role in hemostasis. Deficiencies in Protein S, particularly autosomal dominant forms that result in levels between 15 to 37% of normal, are associated with severe recurrent venous thrombosis, emphasizing the clinical significance of this protein in thrombotic disorders. Protein S monoclonal antibody (C-5) is an essential tool for researchers studying coagulation pathways and related pathologies.
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Protein S Antibody (C-5) References:
- Protein S: a conduit between anticoagulation and inflammation. | Rigby, AC. and Grant, MA. 2004. Crit Care Med. 32: S336-41. PMID: 15118541
- Protein palmitoylation by a family of DHHC protein S-acyltransferases. | Mitchell, DA., et al. 2006. J Lipid Res. 47: 1118-27. PMID: 16582420
- TAM receptors, Gas6, and protein S: roles in inflammation and hemostasis. | van der Meer, JH., et al. 2014. Blood. 123: 2460-9. PMID: 24596417
- Amelioration of Diabetes by Protein S. | Yasuma, T., et al. 2016. Diabetes. 65: 1940-51. PMID: 27207541
- Palmitoylation: a protein S-acylation with implications for breast cancer. | Anderson, AM. and Ragan, MA. 2016. NPJ Breast Cancer. 2: 16028. PMID: 28721385
- Profiling Protein S-Sulfination with Maleimide-Linked Probes. | Kuo, YH., et al. 2017. Chembiochem. 18: 2028-2032. PMID: 28809078
- Thioredoxin 1 regulation of protein S-desulfhydration. | Ju, Y., et al. 2016. Biochem Biophys Rep. 5: 27-34. PMID: 28955804
- Protein S Exacerbates Chronic Liver Injury and Fibrosis. | Totoki, T., et al. 2018. Am J Pathol. 188: 1195-1203. PMID: 29454753
- Unfolded Von Willebrand Factor Binds Protein S and Reduces Anticoagulant Activity. | Sim, MMS., et al. 2024. bioRxiv.. PMID: 38370737
- Recapitulating the potential contribution of protein S-palmitoylation in cancer. | Chaturvedi, S. and Sonawane, A. 2024. Cancer Metastasis Rev. 44: 20. PMID: 39725785
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Protein S Antibody (C-5) | sc-271400 | 200 µg/ml | $316.00 | |||
Protein S Antibody (C-5): m-IgGκ BP-HRP Bundle | sc-534949 | 200 µg Ab; 40 µg BP | $354.00 | |||
Protein S Antibody (C-5): m-IgG2a BP-HRP Bundle | sc-546201 | 200 µg Ab; 10 µg BP | $354.00 |