Protein C Antibody (C-10): sc-377175
- Protein C Antibody (C-10) is a mouse monoclonal IgG1 κ Protein C antibody provided at 200 µg/ml
- raised against amino acids 256-395 mapping near the C-terminus of Protein C of human origin
- Protein C Antibody (C-10) is recommended for detection of Protein C of mouse, rat, human origin by WB, IP, IF and ELISA
- Anti-Protein C Antibody (C-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Protein C Antibody (C-10) for WB applications. These reagents are now offered in bundles with Protein C Antibody (C-10) (see ordering information below).
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Protein C Antibody (C-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects Protein C of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-Protein C antibody (C-10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Protein C is a vitamin K-dependent plasma protein synthesized in the liver, consisting of two polypeptide chains, and plays a crucial role in blood coagulation regulation. Upon activation by thrombin bound to an endothelial surface receptor, Protein C cleaves and inactivates activated forms of coagulation Factors V and VIII, serving as a vital anti-coagulant that helps maintain hemostatic balance. Proper functioning of Protein C is essential, as deficiencies can lead to inherited thrombophilia, a condition that significantly increases venous thrombosis risk and complications such as habitual abortion. Normal concentrations of Protein C in human plasma range from approximately 1-3 ng/ml, while proenzyme concentration is around 3 µg/ml, highlighting Protein C′s importance in the coagulation cascade and overall vascular health.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Protein C Antibody (C-10) References:
- Inflammation and the activated protein C anticoagulant pathway. | Esmon, CT. 2006. Semin Thromb Hemost. 32 Suppl 1: 49-60. PMID: 16673266
- Recombinant human activated protein C upregulates the release of soluble fractalkine from human endothelial cells. | Brueckmann, M., et al. 2006. Br J Haematol. 133: 550-7. PMID: 16681644
- Severe type I protein C deficiency with neonatal purpura fulminans due to a novel homozygous mutation in exon 6 of the protein C gene. | Abu-Amero, KK., et al. 2006. J Thromb Haemost. 4: 1152-3. PMID: 16689776
- The roles of protein C and thrombomodulin in the regulation of blood coagulation. | Esmon, CT. 1989. J Biol Chem. 264: 4743-6. PMID: 2538457
- Inherited thrombophilia: resistance to activated protein C as a pathogenic factor of venous thromboembolism. | Dahlbäck, B. 1995. Blood. 85: 607-14. PMID: 7833465
- Mutation in blood coagulation factor V associated with resistance to activated protein C. | Bertina, RM., et al. 1994. Nature. 369: 64-7. PMID: 8164741
- Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C. | Dahlbäck, B., et al. 1993. Proc Natl Acad Sci U S A. 90: 1004-8. PMID: 8430067
- Increased fetal loss in women with heritable thrombophilia. | Preston, FE., et al. 1996. Lancet. 348: 913-6. PMID: 8843809
- Deficiency of protein C in congenital thrombotic disease. | Griffin, JH., et al. 1981. J Clin Invest. 68: 1370-3. PMID: 6895379
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Protein C Antibody (C-10) | sc-377175 | 200 µg/ml | $316.00 | |||
Protein C Antibody (C-10): m-IgGκ BP-HRP Bundle | sc-523224 | 200 µg Ab, 40 µg BP | $354.00 | |||
Protein C Antibody (C-10): m-IgG1 BP-HRP Bundle | sc-533564 | 200 µg Ab; 20 µg BP | $354.00 | |||
Protein C Antibody (C-10) AC | sc-377175 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Protein C Antibody (C-10) HRP | sc-377175 HRP | 200 µg/ml | $316.00 | |||
Protein C Antibody (C-10) FITC | sc-377175 FITC | 200 µg/ml | $330.00 | |||
Protein C Antibody (C-10) PE | sc-377175 PE | 200 µg/ml | $343.00 | |||
Protein C Antibody (C-10) Alexa Fluor® 488 | sc-377175 AF488 | 200 µg/ml | $357.00 | |||
Protein C Antibody (C-10) Alexa Fluor® 546 | sc-377175 AF546 | 200 µg/ml | $357.00 | |||
Protein C Antibody (C-10) Alexa Fluor® 594 | sc-377175 AF594 | 200 µg/ml | $357.00 | |||
Protein C Antibody (C-10) Alexa Fluor® 647 | sc-377175 AF647 | 200 µg/ml | $357.00 | |||
Protein C Antibody (C-10) Alexa Fluor® 680 | sc-377175 AF680 | 200 µg/ml | $357.00 | |||
Protein C Antibody (C-10) Alexa Fluor® 790 | sc-377175 AF790 | 200 µg/ml | $357.00 |