Prostasin Antibody (2): sc-136272

Prostasin Antibody (2) is a mouse monoclonal IgG2a antibody that detects prostasin in mouse, rat, and human samples through applications such as western blotting (WB) and immunoprecipitation (IP). Prostasin is a serine protease primarily identified in prostate tissue, where prostasin plays a crucial role in activating epithelial sodium channels across various tissues, thereby influencing sodium homeostasis and fluid balance. Prostasin is typically membrane-anchored, yet can also be found in physiological fluids and tissue culture media, suggesting a potential mechanism for secretion from cells. Regulation of prostasin is significant, as aldosterone enhances prostasin expression and promotes sodium uptake, while protease inhibitors like aprotinin can suppress prostasin′s channel-activating capacity. Furthermore, prostasin expression is inversely correlated with DNA methylation in cancer cells, indicating that prostasin activity may serve as a marker for epithelial cell physiology and could impact cancer invasiveness and metastatic potential. Anti-prostasin antibody (2) is an essential tool for researchers investigating the multifaceted roles of prostasin in cellular processes and disease states.

The preferred Prostasin antibody is Prostasin Antibody (C-10): sc-514983.