proenkephalin B Antibody (D-6): sc-398808

proenkephalin B Antibody (D-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects proenkephalin B protein of mouse and rat origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-proenkephalin B antibody (D-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. proenkephalin B protein is a precursor in the opioid neuropeptide family, playing a critical role in the production of bioactive peptides that interact with the κ-opioid receptor, which is essential for modulating pain and stress responses. Notably, proenkephalin B undergoes post-translational modifications, including proteolytic cleavage, to yield several active peptides such as β-neoendorphin and dynorphin, which are involved in various physiological processes, including analgesia and mood regulation. Understanding the processing and function of proenkephalin B is vital, as dysregulation of opioid peptides can lead to conditions such as chronic pain and addiction.

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proenkephalin B Antibody (D-6) References:

1. Increased striatal pre-proenkephalin B expression is associated with dyskinesia in Parkinson's disease.  |  Henry, B., et al. 2003. Exp Neurol. 183: 458-68. PMID: 14552886
2. A new electrochemical HPLC method for analysis of enkephalins and endomorphins.  |  Lisi, TL. and Sluka, KA. 2006. J Neurosci Methods. 150: 74-9. PMID: 16051372
3. Ischemic preconditioning increases the bioavailability of cardiac enkephalins.  |  Younès, A., et al. 2005. Am J Physiol Heart Circ Physiol. 289: H1652-61. PMID: 16162869
4. Leumorphin has an anti-apoptotic effect by activating epidermal growth factor receptor kinase in rat pheochromocytoma PC12 cells.  |  Lee, BD., et al. 2005. J Neurochem. 95: 56-67. PMID: 16181412
5. Nucleotide and amino acid sequence of lymphocyte-derived corticotropin: endotoxin induction of a truncated peptide.  |  Smith, EM., et al. 1990. Proc Natl Acad Sci U S A. 87: 1057-60. PMID: 1689057
6. Corticotropin and beta-endorphin: construction and analysis of recombinant DNA complementary to mRNA for the common precursor.  |  Roberts, JL., et al. 1979. Proc Natl Acad Sci U S A. 76: 2153-7. PMID: 221916
7. Expression of mouse proopiomelanocortin in an insulinoma cell line. Requirements for beta-endorphin processing.  |  Thorne, BA., et al. 1989. J Biol Chem. 264: 3545-52. PMID: 2536749
8. Characterization of proenkephalin B-derived opioid peptides in the human hypothalamo-neurohypophyseal axis.  |  Arendt, RM., et al. 1985. Brain Res. 345: 230-7. PMID: 2864112
9. Methods for estimating the contribution of proenkephalin A and proenkephalin B input to neuronal areas.  |  Sundberg, DK. and Dunlap, CE. 1986. Methods Enzymol. 124: 617-26. PMID: 3713529
10. Evidence for a selective processing of proenkephalin B into different opioid peptide forms in particular regions of rat brain and pituitary.  |  Seizinger, BR., et al. 1984. J Neurochem. 42: 447-57. PMID: 6141221
11. Isolation and characterization of the mouse corticotropin-beta-lipotropin precursor gene and a related pseudogene.  |  Notake, M., et al. 1983. FEBS Lett. 156: 67-71. PMID: 6303853
12. Fragmentation characteristics of neuropeptides related to chromogranin B and proenkephalin B using fast atom bombardment and collision-induced dissociation.  |  Boel, S., et al. 1994. Biol Mass Spectrom. 23: 603-11. PMID: 7986830

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-proenkephalin B Antibody (D-6) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-proenkephalin B Antibody (D-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

proenkephalin B Antibody (D-6) Specifications

Alternate Product Name: proenkephalin B

Product Clone Name: D-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-248

Epitope Target: proenkephalin B

Epitope Species: mouse

Product Reactivity/Detection: proenkephalin B precursor and all processed active peptides

Species Reactivity/Detection: mouse, rat

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for proenkephalin B Antibody (D-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin