PRMT2 Antibody (E-12): sc-390089

PRMT2 Antibody (E-12) is a mouse monoclonal IgG3 antibody that detects PRMT2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PRMT2, a 433 amino acid protein encoded by the human gene PRMT2, plays a crucial role in cellular processes by functioning as a protein arginine N-methyltransferase, which is essential for the post-translational methylation of arginine residues. This modification influences chromatin structure and gene expression, thereby regulating cellular transcription. PRMT2 is involved in inhibiting NF-kappaB-dependent transcription, a pathway critical for controlling inflammation and immune responses. By blocking the nuclear export of IkappaB-alpha, PRMT2 increases nuclear concentration, leading to reduced NF-kappaB DNA binding and promoting apoptosis in response to cytokines or cytotoxic drugs. PRMT2′s ability to modulate these pathways highlights PRMT2′s importance in maintaining cellular homeostasis and potential implications in various diseases, including cancer. Anti-PRMT2 antibody (E-12) serves as an invaluable tool for researchers investigating the roles of protein methylation and NF-kappaB signaling in health and disease.

The preferred PRMT2 antibody is PRMT2 Antibody (B-11): sc-393254.