PRMT2 Activators
PRMT2 activators encompass a group of chemicals that enhance the enzymatic activity of Protein Arginine Methyltransferase 2 (PRMT2). PRMT2 is an enzyme that belongs to the family of protein arginine methyltransferases, which are responsible for the methylation of arginine residues on various substrate proteins, a post-translational modification that affects protein function and interaction. The activators of PRMT2 target the enzyme in different ways, potentially by increasing its expression, by enhancing the affinity of the enzyme for its substrates, or by influencing the enzyme's catalytic activity directly. The precise molecular mechanisms by which these activators exert their effects can vary widely, ranging from direct binding to the active site of the enzyme to allosteric modulation that changes the enzyme's conformation and, consequently, its activity.
The activation of PRMT2 can have profound implications for the myriad of biological processes in which arginine methylation plays a role. For instance, PRMT2 activators may amplify the methylation of histones, which can influence chromatin structure and gene expression. Additionally, through the methylation of non-histone proteins, these activators can impact cellular signaling, RNA processing, and protein-protein interactions. The biochemical pathways engaged by PRMT2 activators are complex, and the downstream effects of PRMT2 activation are diverse, reflecting the enzyme's involvement in multiple facets of cellular function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $184.00 $668.00 | 2 | |
SAM serves as the methyl donor in numerous methylation reactions catalyzed by PRMTs. By providing the methyl groups required for these reactions, increased availability of SAM could enhance the functional activity of PRMT2. | ||||||
Mecobalamin | 13422-55-4 | sc-211781 | 10 mg | $306.00 | ||
Methylcobalamin, a form of vitamin B12, is a cofactor necessary for the synthesis of methionine and subsequently SAM. An abundance of methylcobalamin may indirectly support PRMT2 activity by ensuring adequate levels of SAM. | ||||||
Betaine | 107-43-7 | sc-214595 sc-214595A sc-214595B sc-214595C sc-214595D sc-214595E | 50 g 100 g 250 g 1 kg 2.5 kg 5 kg | $31.00 $41.00 $56.00 $163.00 $337.00 $592.00 | 2 | |
Betaine donates a methyl group to homocysteine to form methionine, which is a precursor to SAM. Increased betaine levels could potentially lead to increased SAM availability, influencing PRMT2 methyltransferase activity. | ||||||
Folic Acid | 59-30-3 | sc-204758 | 10 g | $73.00 | 2 | |
Folic acid is critical for the methylation cycle and indirectly supports the regeneration of SAM. Adequate folic acid levels are necessary for one-carbon metabolism which, in turn, could support the methylation activity of PRMT2. | ||||||
Riboflavin | 83-88-5 | sc-205906 sc-205906A sc-205906B | 25 g 100 g 1 kg | $41.00 $112.00 $525.00 | 3 | |
Riboflavin, or vitamin B2, is a precursor for FAD, a coenzyme involved in the synthesis of methionine from homocysteine. Through this pathway, riboflavin availability may affect PRMT2 activity indirectly. | ||||||
Pyridoxal-5-phosphate | 54-47-7 | sc-205825 | 5 g | $104.00 | ||
Pyridoxal phosphate, the active form of vitamin B6, is a cofactor for enzymes in the methionine synthesis pathway. It may indirectly modulate PRMT2 activity through its role in homocysteine metabolism. | ||||||
Choline chloride | 67-48-1 | sc-207430 sc-207430A sc-207430B | 10 mg 5 g 50 g | $33.00 $37.00 $52.00 | 1 | |
Choline can be oxidized to betaine, which donates methyl groups to homocysteine to form methionine. Increased choline levels may indirectly increase PRMT2 activity by enhancing methyl group availability for SAM production. | ||||||
Creatine, anhydrous | 57-00-1 | sc-214774 sc-214774A | 10 mg 50 g | $28.00 $79.00 | 2 | |
Creatine synthesis consumes SAM, potentially reducing its availability for other methylation reactions. Conversely, supplementing with creatine may spare SAM and indirectly support PRMT2 activity. | ||||||
L-Methionine | 63-68-3 | sc-394076 sc-394076A sc-394076B sc-394076C sc-394076D sc-394076E | 25 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $37.00 $57.00 $151.00 $577.00 $1103.00 | ||
Methionine directly contributes to the SAM synthesis pathway. Supplementing methionine could enhance SAM levels, providing more methyl donors for PRMT2 catalytic activity. | ||||||
Glycine | 56-40-6 | sc-29096A sc-29096 sc-29096B sc-29096C | 500 g 1 kg 3 kg 10 kg | $41.00 $71.00 $112.00 $357.00 | 15 | |
Glycine contributes to one-carbon metabolism and may thereby influence SAM regeneration. This could indirectly affect PRMT2 activity by altering the availability of methyl groups. | ||||||