PRMT1 Antibody (PRMT1-171): sc-59648

PRMT1 Antibody (PRMT1-171) is a mouse monoclonal IgG1 antibody that detects PRMT1 in mouse, rat, human, bovine, and canine samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). PRMT1 Antibody (PRMT1-171) is offered in a non-conjugated form, allowing for versatile experimental use. PRMT1, a member of the type 1 protein arginine N-methyltransferase family, plays a crucial role in post-translational modification of RNA-binding proteins, which is essential for regulating various cellular processes, including gene expression and signal transduction. PRMT1 is predominantly localized in the nucleus, where PRMT1 interacts with various nuclear substrates, influencing their function and stability. PRMT1′s activity is modulated by interaction with interleukin enhancer-binding factor 3 (ILF3) at the carboxy-terminus, which is vital for maintaining proper PRMT1 function. Alternative mRNA splicing of the PRMT gene results in three isoforms of PRMT1, each exhibiting enzymatic activity but differing in their amino-terminus regions, which may confer unique regulatory properties. Understanding PRMT1 dynamics and interactions is critical for elucidating PRMT1′s role in cellular regulation and potential implications in disease states.

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PRMT1 Antibody (PRMT1-171) References:

1. PRMT1 is the predominant type I protein arginine methyltransferase in mammalian cells.  |  Tang, J., et al. 2000. J Biol Chem. 275: 7723-30. PMID: 10713084
2. Protein-arginine methyltransferase I, the predominant protein-arginine methyltransferase in cells, interacts with and is regulated by interleukin enhancer-binding factor 3.  |  Tang, J., et al. 2000. J Biol Chem. 275: 19866-76. PMID: 10749851
3. PRMT3 is a distinct member of the protein arginine N-methyltransferase family. Conferral of substrate specificity by a zinc-finger domain.  |  Frankel, A. and Clarke, S. 2000. J Biol Chem. 275: 32974-82. PMID: 10931850
4. Genomic organization, physical mapping, and expression analysis of the human protein arginine methyltransferase 1 gene.  |  Scorilas, A., et al. 2000. Biochem Biophys Res Commun. 278: 349-59. PMID: 11097842
5. Structure of the predominant protein arginine methyltransferase PRMT1 and analysis of its binding to substrate peptides.  |  Zhang, X. and Cheng, X. 2003. Structure. 11: 509-20. PMID: 12737817
6. Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53.  |  An, W., et al. 2004. Cell. 117: 735-48. PMID: 15186775
7. Arginine methylation of MRE11 by PRMT1 is required for DNA damage checkpoint control.  |  Boisvert, FM., et al. 2005. Genes Dev. 19: 671-6. PMID: 15741314
8. CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growth.  |  Yin, S., et al. 2023. Cell Rep. 42: 112316. PMID: 36995937
9. PRMT1 mediated methylation of cGAS suppresses anti-tumor immunity.  |  Liu, J., et al. 2023. Nat Commun. 14: 2806. PMID: 37193698
10. PRMT1 orchestrates with SAMTOR to govern mTORC1 methionine sensing via Arg-methylation of NPRL2.  |  Jiang, C., et al. 2023. Cell Metab. 35: 2183-2199.e7. PMID: 38006878
11. FBXO7 ubiquitinates PRMT1 to suppress serine synthesis and tumor growth in hepatocellular carcinoma.  |  Luo, L., et al. 2024. Nat Commun. 15: 4790. PMID: 38839752
12. PRMT 3, a type I protein arginine N-methyltransferase that differs from PRMT1 in its oligomerization, subcellular localization, substrate specificity, and regulation.  |  Tang, J., et al. 1998. J Biol Chem. 273: 16935-45. PMID: 9642256

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PRMT1 Antibody (PRMT1-171) has 11 citations in a variety of scientific publications.

Primary antibodies like Anti-PRMT1 Antibody (PRMT1-171) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PRMT1 Antibody (PRMT1-171) Specifications

Alternate Product Name: PRMT1

Product Clone Name: PRMT1-171

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: PRMT1

Epitope Species: human

Product Reactivity/Detection: PRMT1

Species Reactivity/Detection: mouse, rat, human, bovine, canine

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 11 citations in various scientific publications

Available Conjugates/Forms for PRMT1 Antibody (PRMT1-171): N/A