PRMT1 Antibody (G-6): sc-271404

PRMT1 Antibody (G-6) is a mouse monoclonal IgG2a antibody that detects PRMT1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PRMT1, a member of the type 1 protein arginine N-methyltransferase family, plays a crucial role in the post-translational modification of RNA-binding proteins, which is essential for regulating gene expression and RNA processing. Located predominantly in the nucleus, PRMT1 interacts with various proteins, including Interleukin enhancer-binding factor 3 (ILF3), which modulates activity and highlights the importance of protein-protein interactions in cellular regulation. Notably, PRMT1 exists in three isoforms resulting from alternative mRNA splicing, all of which retain enzymatic activity but differ in their amino terminus regions, allowing for diverse functional roles in cellular processes. The ability of anti-PRMT1 antibody (G-6) to form heterodimers with other PRMT family members, such as PRMT8, further emphasizes significance in the context of neuronal differentiation and tissue-specific expression. With versatile applications and critical role in cellular function, PRMT1 (G-6) antibody serves as an invaluable tool for researchers studying the dynamics of arginine methylation and implications in various biological processes.

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PRMT1 Antibody (G-6) References:

1. Roles of protein arginine methyltransferase 1 (PRMT1) in brain development and disease.  |  Hashimoto, M., et al. 2021. Biochim Biophys Acta Gen Subj. 1865: 129776. PMID: 33127433
2. PRMT1 inhibition promotes ferroptosis sensitivity via ACSL1 upregulation in acute myeloid leukemia.  |  Zhou, L., et al. 2023. Mol Carcinog. 62: 1119-1135. PMID: 37144835
3. PRMT1 promotes the proliferation and metastasis of gastric cancer cells by recruiting MLXIP for the transcriptional activation of the β-catenin pathway.  |  Wang, F., et al. 2023. Genes Dis. 10: 2622-2638. PMID: 37554218
4. PRMT1 methylation of WTAP promotes multiple myeloma tumorigenesis by activating oxidative phosphorylation via m6A modification of NDUFS6.  |  Jia, Y., et al. 2023. Cell Death Dis. 14: 512. PMID: 37558663
5. Methylation of BRD4 by PRMT1 regulates BRD4 phosphorylation and promotes ovarian cancer invasion.  |  Liu, Y., et al. 2023. Cell Death Dis. 14: 624. PMID: 37737256
6. The arginine methyltransferase Prmt1 coordinates the germline arginine methylome essential for spermatogonial homeostasis and male fertility.  |  Azhar, M., et al. 2023. Nucleic Acids Res. 51: 10428-10450. PMID: 37739418
7. Hematopoietic stem cell quiescence and DNA replication dynamics maintained by the resilient β-catenin/Hoxa9/Prmt1 axis.  |  Lynch, J., et al. 2024. Blood. 143: 1586-1598. PMID: 38211335
8. PRMT1 promotes epigenetic reprogramming associated with acquired chemoresistance in pancreatic cancer.  |  Nguyen, CDK., et al. 2024. Cell Rep. 43: 114176. PMID: 38691454
9. PRMT1 promotes Warburg effect by regulating the PKM2/PKM1 ratio in non-small cell lung cancer.  |  Peng, L., et al. 2024. Cell Death Dis. 15: 504. PMID: 39009589
10. Arginine Methylation of DDX3 by PRMT1 Mediates Mitochondrial Homeostasis to Promote Breast Cancer Metastasis.  |  Hsu, WJ., et al. 2024. Cancer Res. 84: 3023-3043. PMID: 39042374

The preferred PRMT1 antibody is PRMT1 Antibody (PRMT1-171): sc-59648.