PQBP-1 Antibody (B-9): sc-374260
- PQBP-1 Antibody (B-9) is a mouse monoclonal IgG1 κ PQBP-1 antibody, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 1-265 representing full length PQBP-1 of human origin
- PQBP-1 Antibody (B-9) is recommended for detection of PQBP-1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-PQBP-1 Antibody (B-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- TransCruz reagent for ChIP application (sc-374260 X, 200 µg/0.1 ml)
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of PQBP-1 (B-9): sc-374260.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for PQBP-1 Antibody (B-9) for WB and IHC(P) applications. These reagents are now offered in bundles with PQBP-1 Antibody (B-9) (see ordering information below).
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PQBP-1 Antibody (B-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects PQBP-1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). PQBP-1 (B-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Polyglutamine tract binding protein-1 (PQBP-1) plays a crucial role as a transcription repressor, interacting with polyglutamine tract-containing transcription regulators and genes associated with neurodegenerative disorders, making PQBP-1 vital for understanding molecular mechanisms underlying these conditions. PQBP-1 structure includes a WWP/WW domain that binds proline-rich motifs and a C2 domain influencing calcium-dependent phospholipid signaling, essential for cellular signaling pathways. PQBP-1 predominantly localizes in the nucleus and shows high expression in neurons throughout the brain, particularly in the hippocampus, cerebellar cortex, and olfactory bulb, highlighting PQBP-1′s importance in neuronal function and health. Human PQBP-1 gene location on chromosome Xp11.23 further emphasizes PQBP-1′s relevance in genetic studies related to neurodegenerative diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PQBP-1 Antibody (B-9) References:
- Npw38, a novel nuclear protein possessing a WW domain capable of activating basal transcription. | Komuro, A., et al. 1999. Nucleic Acids Res. 27: 1957-65. PMID: 10198427
- PQBP-1, a novel polyglutamine tract-binding protein, inhibits transcription activation by Brn-2 and affects cell survival. | Waragai, M., et al. 1999. Hum Mol Genet. 8: 977-87. PMID: 10332029
- PQBP-1/Npw38, a nuclear protein binding to the polyglutamine tract, interacts with U5-15kD/dim1p via the carboxyl-terminal domain. | Waragai, M., et al. 2000. Biochem Biophys Res Commun. 273: 592-5. PMID: 10873650
- Genomic organization and alternative transcripts of the human PQBP-1 gene. | Iwamoto, K., et al. 2000. Gene. 259: 69-73. PMID: 11163963
- PQBP-1 (Np/PQ): a polyglutamine tract-binding and nuclear inclusion-forming protein. | Okazawa, H., et al. Brain Res Bull. 56: 273-80. PMID: 11719261
- Interaction between mutant ataxin-1 and PQBP-1 affects transcription and cell death. | Okazawa, H., et al. 2002. Neuron. 34: 701-13. PMID: 12062018
- Polar amino acid-rich sequences bind to polyglutamine tracts. | Imafuku, I., et al. 1998. Biochem Biophys Res Commun. 253: 16-20. PMID: 9875212
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PQBP-1 Antibody (B-9) | sc-374260 | 200 µg/ml | $316.00 | |||
PQBP-1 Antibody (B-9): m-IgG Fc BP-HRP Bundle | sc-527448 | 200 µg Ab; 10 µg BP | $354.00 | |||
PQBP-1 Antibody (B-9): m-IgG1 BP-HRP Bundle | sc-532821 | 200 µg Ab; 20 µg BP | $354.00 | |||
PQBP-1 Antibody (B-9) X | sc-374260 X | 200 µg/0.1 ml | $316.00 | |||
PQBP-1 Antibody (B-9) AC | sc-374260 AC | 500 µg/ml, 25% agarose | $416.00 | |||
PQBP-1 Antibody (B-9) HRP | sc-374260 HRP | 200 µg/ml | $316.00 | |||
PQBP-1 Antibody (B-9) FITC | sc-374260 FITC | 200 µg/ml | $330.00 | |||
PQBP-1 Antibody (B-9) PE | sc-374260 PE | 200 µg/ml | $343.00 | |||
PQBP-1 Antibody (B-9) Alexa Fluor® 488 | sc-374260 AF488 | 200 µg/ml | $357.00 | |||
PQBP-1 Antibody (B-9) Alexa Fluor® 546 | sc-374260 AF546 | 200 µg/ml | $357.00 | |||
PQBP-1 Antibody (B-9) Alexa Fluor® 594 | sc-374260 AF594 | 200 µg/ml | $357.00 | |||
PQBP-1 Antibody (B-9) Alexa Fluor® 647 | sc-374260 AF647 | 200 µg/ml | $357.00 | |||
PQBP-1 Antibody (B-9) Alexa Fluor® 680 | sc-374260 AF680 | 200 µg/ml | $357.00 | |||
PQBP-1 Antibody (B-9) Alexa Fluor® 790 | sc-374260 AF790 | 200 µg/ml | $357.00 |