PPPDE2 Antibody (A-6): sc-393863
- PPPDE2 Antibody (A-6) is a mouse monoclonal IgG1 κ PPPDE2 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 51-72 within an internal region of PPPDE2 of human origin
- PPPDE2 Antibody (A-6) is recommended for detection of PPPDE2 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including canine
- Anti-PPPDE2 Antibody (A-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for PPPDE2 Antibody (A-6) for WB applications. These reagents are now offered in bundles with PPPDE2 Antibody (A-6) (see ordering information below).
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PPPDE2 Antibody (A-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects PPPDE2 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PPPDE2 Antibody (A-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PPPDE2, also known as FAM152B, is a 168 amino acid homodimeric protein that belongs to the DeSI family and is primarily localized in the nucleus and cytoplasm. PPPDE2′s critical function involves the deconjugation of small ubiquitin-like modifier proteins (SUMO1, SUMO2, and SUMO3), which plays a significant role in regulating various cellular processes, including transcriptional regulation, DNA repair, and cellular stress responses. PPPDE2 exhibits isopeptidase activity but lacks SUMO-processing activity, highlighting a specific role in the SUMO pathway. The gene encoding PPPDE2 is located on human chromosome 22, which houses over 500 genes and is implicated in several genetic disorders, including Phelan-McDermid syndrome and Neurofibromatosis type 2. Additionally, chromosome 22 is associated with the Philadelphia Chromosome, which can lead to the formation of the BCR-Abl fusion protein, a key player in certain leukemias.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PPPDE2 Antibody (A-6) References:
- [Chromosome 22q11 deletion syndrome and its relevance for child and adolescent psychiatry. An overview of etiology, physical symptoms, aspects of child development and psychiatric disorders]. | Briegel, W. and Cohen, M. 2004. Z Kinder Jugendpsychiatr Psychother. 32: 107-15. PMID: 15181786
- A genome annotation-driven approach to cloning the human ORFeome. | Collins, JE., et al. 2004. Genome Biol. 5: R84. PMID: 15461802
- Genes, brain development and psychiatric phenotypes in velo-cardio-facial syndrome. | Gothelf, D., et al. 2008. Dev Disabil Res Rev. 14: 59-68. PMID: 18636637
- Association of the PIK4CA schizophrenia-susceptibility gene in adults with the 22q11.2 deletion syndrome. | Vorstman, JA., et al. 2009. Am J Med Genet B Neuropsychiatr Genet. 150B: 430-3. PMID: 18646052
- A quantitative atlas of mitotic phosphorylation. | Dephoure, N., et al. 2008. Proc Natl Acad Sci U S A. 105: 10762-7. PMID: 18669648
- Array analysis and molecular studies of INI1 in an infant with deletion 22q13 (Phelan-McDermid syndrome) and atypical teratoid/rhabdoid tumor. | Sathyamoorthi, S., et al. 2009. Am J Med Genet A. 149A: 1067-9. PMID: 19334084
- Neurofibromatosis 2 [Bilateral acoustic neurofibromatosis, central neurofibromatosis, NF2, neurofibromatosis type II]. | Evans, DG. 2009. Genet Med. 11: 599-610. PMID: 19652604
- Molecular pathogenesis of Philadelphia-positive chronic myeloid leukemia - is it all BCR-ABL? | Rumpold, H. and Webersinke, G. 2011. Curr Cancer Drug Targets. 11: 3-19. PMID: 21062244
- Initial characterization of the human central proteome. | Burkard, TR., et al. 2011. BMC Syst Biol. 5: 17. PMID: 21269460
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PPPDE2 Antibody (A-6) | sc-393863 | 200 µg/ml | $322.00 | |||
PPPDE2 Antibody (A-6): m-IgG Fc BP-HRP Bundle | sc-530611 | 200 µg Ab; 10 µg BP | $361.00 | |||
PPPDE2 Antibody (A-6): m-IgGκ BP-HRP Bundle | sc-524125 | 200 µg Ab, 40 µg BP | $361.00 | |||
PPPDE2 Antibody (A-6): m-IgG1 BP-HRP Bundle | sc-544162 | 200 µg Ab; 20 µg BP | $361.00 | |||
PPPDE2 Antibody (A-6) AC | sc-393863 AC | 500 µg/ml, 25% agarose | $424.00 | |||
PPPDE2 Antibody (A-6) HRP | sc-393863 HRP | 200 µg/ml | $322.00 | |||
PPPDE2 Antibody (A-6) FITC | sc-393863 FITC | 200 µg/ml | $336.00 | |||
PPPDE2 Antibody (A-6) PE | sc-393863 PE | 200 µg/ml | $349.00 | |||
PPPDE2 Antibody (A-6) Alexa Fluor® 488 | sc-393863 AF488 | 200 µg/ml | $364.00 | |||
PPPDE2 Antibody (A-6) Alexa Fluor® 546 | sc-393863 AF546 | 200 µg/ml | $364.00 | |||
PPPDE2 Antibody (A-6) Alexa Fluor® 594 | sc-393863 AF594 | 200 µg/ml | $364.00 | |||
PPPDE2 Antibody (A-6) Alexa Fluor® 647 | sc-393863 AF647 | 200 µg/ml | $364.00 | |||
PPPDE2 Antibody (A-6) Alexa Fluor® 680 | sc-393863 AF680 | 200 µg/ml | $364.00 | |||
PPPDE2 Antibody (A-6) Alexa Fluor® 790 | sc-393863 AF790 | 200 µg/ml | $364.00 | |||
PPPDE2 (A-6) Neutralizing Peptide | sc-393863 P | 100 µg/0.5 ml | $69.00 |