PPIH Antibody (G-6): sc-377420
- PPIH Antibody (G-6) is a mouse monoclonal IgM provided at 200 µg/ml
- specific for an epitope mapping between amino acids 151-174 at the C-terminus of PPIH of human origin
- recommended for detection of PPIH of mouse, rat, human and avian origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine, porcine and avian
- TransCruz reagent for ChIP application (sc-377420 X, 200 µg/0.1 ml)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PPIH Antibody (G-6). This work is in progress.
QUICK LINKS
SEE ALSO...
PPIH Antibody (G-6) is a mouse monoclonal IgM antibody that detects PPIH (peptidylprolyl isomerase H) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PPIH is a 177 amino acid protein belonging to the cyclophilin-type peptidylprolyl isomerase family, and plays a crucial role in protein folding by catalyzing the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. This function facilitates proper protein folding, essential for stability and functionality. PPIH is implicated in pre-mRNA splicing, interacting with processing factors such as PRPF3, PRPF4, and PRPF18, and contributes to the assembly of the U4/U5/U6 tri-snRNP complex, highlighting importance in the spliceosome′s function. As a protein chaperone, PPIH possesses peptidylprolyl isomerase activity and mediates interactions between various proteins within the spliceosome, making PPIH a key player in gene expression regulation. PPIH contains one PPIase cyclophilin-type domain and is inhibited by cyclosporin A, emphasizing significance in cellular processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PPIH Antibody (G-6) References:
- Dietary Inulin Fibers Prevent Proton-Pump Inhibitor (PPI)-Induced Hypocalcemia in Mice. | Hess, MW., et al. 2015. PLoS One. 10: e0138881. PMID: 26397986
- The spliceosomal proteins PPIH and PRPF4 exhibit bi-partite binding. | Rajiv, C., et al. 2017. Biochem J. 474: 3689-3704. PMID: 28935721
- Structural and Functional Insights into Human Nuclear Cyclophilins. | Rajiv, C. and Davis, TL. 2018. Biomolecules. 8: PMID: 30518120
- Mass spectrometric analysis of TRPM6 and TRPM7 from small intestine of omeprazole-induced hypomagnesemic rats. | Kampuang, N. and Thongon, N. 2022. Front Oncol. 12: 947899. PMID: 36110961
- Preparation, characterization, and evaluation of flaxseed oil liposomes coated with chitosan and pea protein isolate hydrolysates. | Song, F., et al. 2023. Food Chem. 404: 134547. PMID: 36240554
- Chaperoning activity of the cyclophilin family prevents tau aggregation. | Hill, SE., et al. 2022. Protein Sci. 31: e4448. PMID: 36305768
- Proton pump inhibitors, bone and phosphocalcic metabolism. | Philippoteaux, C., et al. 2024. Joint Bone Spine. 91: 105714. PMID: 38458487
- PPIH as a poor prognostic factor increases cell proliferation and m6A RNA methylation in hepatocellular carcinoma. | Chi, XX., et al. 2024. Am J Cancer Res. 14: 3733-3756. PMID: 39267679
- PPIH Expression Correlates with Tumor Aggressiveness and Immune Dysregulation in Hepatocellular Carcinoma. | Bei, J., et al. 2024. J Hepatocell Carcinoma. 11: 2453-2470. PMID: 39679070
- D-D dimers: a poor correlate of PPIH and subsequent outcomes. | Royle, G., et al. 1998. Int J Gynaecol Obstet. 62: 37-42. PMID: 9722123
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PPIH Antibody (G-6) | sc-377420 | 200 µg/ml | $322.00 | |||
PPIH (G-6) Neutralizing Peptide | sc-377420 P | 100 µg/0.5 ml | $69.00 | |||
PPIH Antibody (G-6) X | sc-377420 X | 200 µg/0.1 ml | $322.00 |