PP2B-Aβ Antibody (A-11): sc-365612

PP2B-Aβ Antibody (A-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects PP2B-A beta protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-PP2B-A beta antibody (A-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PP2B-A beta protein plays a crucial role in regulating cellular signaling pathways through serine/threonine phosphatase function, which is essential for processes such as cell division, apoptosis, and maintaining cellular homeostasis. PP2B-A beta protein is primarily located in the cytoplasm and nucleus, where PP2B-A beta protein interacts with various substrates to modulate phosphorylation status, thereby influencing numerous cellular functions. PP2B-A beta protein′s ability to dephosphorylate target proteins is vital for fine-tuning signaling cascades, making PP2B-A beta protein a key player in cellular responses to external stimuli. PP2B-A beta protein is part of a larger family of protein phosphatases, which includes other subunits that contribute to regulatory mechanisms, highlighting PP2B-A beta protein′s importance in maintaining cellular balance and function.

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PP2B-Aβ Antibody (A-11) References:

1. Structure and expression of two isoforms of the murine calmodulin-dependent protein phosphatase regulatory subunit (calcineurin B).  |  Ueki, K., et al. 1992. Biochem Biophys Res Commun. 187: 537-43. PMID: 1325794
2. PPP3CB contributes to poor prognosis through activating nuclear factor of activated T-cells signaling in neuroblastoma.  |  Shakhova, I., et al. 2019. Mol Carcinog. 58: 426-435. PMID: 30457174
3. Calcineurin (PPP3CB) regulates angiotensin II-dependent vascular remodelling by potentiating EGFR signalling in mice.  |  Nolze, A., et al. 2021. Acta Physiol (Oxf). 233: e13715. PMID: 34228904
4. PPP3CB Inhibits Cell Proliferation and the Warburg Effect in Bladder Cancer by Blocking PDHK1.  |  Qiu, X., et al. 2024. Front Biosci (Landmark Ed). 29: 48. PMID: 38420800
5. SMURF1 mediates damaged lysosomal homeostasis by ubiquitinating PPP3CB to promote the activation of TFEB.  |  Xia, Q., et al. 2024. Autophagy. 1-18. PMID: 39324484
6. PPP3CB overexpression mediates EGFR TKI resistance in lung tumors via calcineurin/MEK/ERK signaling.  |  Gazzeri, S., et al. 2024. Life Sci Alliance. 7: PMID: 39353739
7. Serine/threonine protein phosphatases.  |  Wera, S. and Hemmings, BA. 1995. Biochem J. 311 (Pt 1): 17-29. PMID: 7575450
8. Important roles for novel protein phosphatases dephosphorylating serine and threonine residues.  |  Cohen, PT. 1993. Biochem Soc Trans. 21: 884-8. PMID: 8132087
9. A regulatory subunit of smooth muscle myosin bound phosphatase.  |  Okubo, S., et al. 1994. Biochem Biophys Res Commun. 200: 429-34. PMID: 8166716
10. Structure and expression of a 72-kDa regulatory subunit of protein phosphatase 2A. Evidence for different size forms produced by alternative splicing.  |  Hendrix, P., et al. 1993. J Biol Chem. 268: 15267-76. PMID: 8392071
11. Protein serine/threonine phosphatases: structure, regulation, and functions in cell growth.  |  Mumby, MC. and Walter, G. 1993. Physiol Rev. 73: 673-99. PMID: 8415923
12. Insights derived from the structures of the Ser/Thr phosphatases calcineurin and protein phosphatase 1.  |  Lohse, DL., et al. 1995. Structure. 3: 987-90. PMID: 8590008

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PP2B-Aβ Antibody (A-11) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-PP2B-Aβ Antibody (A-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PP2B-Aβ Antibody (A-11) Specifications

Alternate Product Name: PP2B-Aβ

Product Clone Name: A-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 499-524

Epitope Target: PP2B-Aβ

Epitope Species: human

Product Reactivity/Detection: PP2B-Aβ

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for PP2B-Aβ Antibody (A-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin